Identification of hPin1 inhibitors that induce apoptosis in a mammalian Ras transformed cell line

The authors have developed a class of potent inhibitors against the phosphate specific prolyl isomerase hPin1, which induced apoptosis in transformed cell lines.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2005-01 (4), p.516-518
Hauptverfasser:	Bayer, Elena, Thutewohl, Michael, Christner, Claudia, Tradler, Thomas, Osterkamp, Frank, Waldmann, Herbert, Bayer, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Cell Line Cell Transformation, Neoplastic - drug effects Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Molecular Structure NIMA-Interacting Peptidylprolyl Isomerase Peptidylprolyl Isomerase - antagonists & inhibitors ras Proteins - metabolism
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Beschreibung
Zusammenfassung:	The authors have developed a class of potent inhibitors against the phosphate specific prolyl isomerase hPin1, which induced apoptosis in transformed cell lines.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b414037k