Selective attachment and release of a chemotherapeutic agent from the interior of a protein cage architecture

The antitumor agent doxorubicin was covalently bound and selectively released in a pH dependent manner from the interior surface of a genetically modified small heat shock protein (Hsp) cage.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2005-01 (4), p.447-449
Hauptverfasser:	Flenniken, Michelle L, Liepold, Lars O, Crowley, Bridgid E, Willits, Deborah A, Young, Mark J, Douglas, Trevor
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - chemistry Doxorubicin - chemistry Drug Delivery Systems - methods Electrophoresis, Polyacrylamide Gel Heat-Shock Proteins - chemistry Heat-Shock Proteins - genetics Methanococcus - chemistry Protein Engineering Protein Subunits - chemistry Protein Subunits - genetics
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Beschreibung
Zusammenfassung:	The antitumor agent doxorubicin was covalently bound and selectively released in a pH dependent manner from the interior surface of a genetically modified small heat shock protein (Hsp) cage.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b413435d