STOP! In the name of positive selection

STOP! In the name of positive selection

Calcium signaling is essential during thymocyte development. It seems that calcium oscillations trigger thymocytes to become immotile, prolonging interactions with stromal cells that are critical for positive selection.

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Bibliographische Detailangaben
Veröffentlicht in:Nature immunology 2005-02, Vol.6 (2), p.126-128
1. Verfasser: Cahalan, Michael D
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Calcium Signaling
Cell Differentiation
Cell Movement
Immunology
Infectious Diseases
news-and-views
Stromal Cells - cytology
Stromal Cells - metabolism
Thymus Gland - cytology
Thymus Gland - immunology
Thymus Gland - metabolism
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Beschreibung
Zusammenfassung:Calcium signaling is essential during thymocyte development. It seems that calcium oscillations trigger thymocytes to become immotile, prolonging interactions with stromal cells that are critical for positive selection.
ISSN:1529-2908
1529-2916
DOI:10.1038/ni0205-126