Transnitrosation of Nitrosothiols: Characterization of an Elusive Intermediate

We report an investigation of the reaction between (S)-nitroso-l-cysteine ethyl ester and l-cysteine ethyl ester as a model of physiologically relevant transnitrosation processes. Our theoretical and experimental evidence clearly supports the existence of a nitroxyl disulfide intermediate in solutio...

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Veröffentlicht in:	Journal of the American Chemical Society 2005-01, Vol.127 (2), p.486-487
Hauptverfasser:	Perissinotti, Laura L, Turjanski, Adrián G, Estrin, Darío A, Doctorovich, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemistry Cysteine - analogs & derivatives Cysteine - chemistry Exact sciences and technology Fundamental and applied biological sciences. Psychology Kinetics Kinetics and mechanisms Magnetic Resonance Spectroscopy Mechanisms. Catalysis. Electron transfer. Models Models, Molecular Molecular biophysics Nitrosation Nitroso Compounds - chemistry Organic chemistry Physical chemistry in biology Reactivity and mechanisms Thermodynamics
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Beschreibung
Zusammenfassung:	We report an investigation of the reaction between (S)-nitroso-l-cysteine ethyl ester and l-cysteine ethyl ester as a model of physiologically relevant transnitrosation processes. Our theoretical and experimental evidence clearly supports the existence of a nitroxyl disulfide intermediate in solution.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja044056v