Acceleration of the Morita−Baylis−Hillman Reaction by a Simple Mixed Catalyst System

Acceleration of the Morita−Baylis−Hillman Reaction by a Simple Mixed Catalyst System

By using a catalytic amount of 4-dimethylaminopyridine (DMAP) as a nucleophile in the presence of an equal amount of tetramethylethylenediamine (TMEDA) and MgI2, Morita−Baylis−Hillman adducts can be obtained in good to excellent yields from various aromatic and aliphatic aldehydes and cyclic enones/...

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Veröffentlicht in:Journal of organic chemistry 2009-06, Vol.74 (12), p.4638-4641
Hauptverfasser: Bugarin, Alejandro, Connell, Brian T
Format: Artikel
Sprache:eng
Schlagworte:
Aliphatic compounds
Catalysis
Catalysts: preparations and properties
Chemistry
Exact sciences and technology
General and physical chemistry
Kinetics and mechanisms
Organic chemistry
Preparations and properties
Reactivity and mechanisms
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Zusammenfassung:By using a catalytic amount of 4-dimethylaminopyridine (DMAP) as a nucleophile in the presence of an equal amount of tetramethylethylenediamine (TMEDA) and MgI2, Morita−Baylis−Hillman adducts can be obtained in good to excellent yields from various aromatic and aliphatic aldehydes and cyclic enones/enoates at room temperature after convenient reaction times.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo900603w