Sustained response to interferon alpha-2a in thalassemic patients with chronic hepatitis C. A prospective 8-year follow-up study

Eighty-nine thalassemic patients with chronic hepatitis C were treated with interferon alpha-2a for 12 months and followed up for 8 years. Interferon induced sustained virologic and biochemical response in 45% of participants and histologic improvement in 50% of patients who had paired liver biopsie...

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Veröffentlicht in:	Haematologica (Roma) 2005-01, Vol.90 (1), p.129-131
Hauptverfasser:	Syriopoulou, V, Daikos, GL, Kostaridou, SL, Manolaki, N, Nakopoulou, L, Kattamis, A, Kattamis, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult beta-Thalassemia - blood beta-Thalassemia - complications beta-Thalassemia - drug therapy Female Follow-Up Studies Hepatitis C, Chronic - blood Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy Humans Interferon-alpha - therapeutic use Male Prospective Studies Recombinant Proteins RNA, Viral - blood
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Zusammenfassung:	Eighty-nine thalassemic patients with chronic hepatitis C were treated with interferon alpha-2a for 12 months and followed up for 8 years. Interferon induced sustained virologic and biochemical response in 45% of participants and histologic improvement in 50% of patients who had paired liver biopsies. Splenectomy was the only independent predictor of an unfavorable outcome.
ISSN:	0390-6078 1592-8721