Cutaneous lymphocyte antigen-positive T cells may predict the development of acute GVHD: alterations and differences of CLA+ T- and NK-cell fractions

Acute GVHD (aGVHD) is a serious complication after allogeneic SCT (allo-SCT). However, an adequate immunological index is not yet available for assessing its severity. We analyzed the fraction of cutaneous lymphocyte antigen (CLA) + cells in peripheral blood T and natural killer (NK) cells in 33 pat...

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Veröffentlicht in:Bone marrow transplantation (Basingstoke) 2009-06, Vol.43 (11), p.863-873
Hauptverfasser: Tsuchiyama, J, Yoshino, T, Saito, T, Furukawa, T, Ito, K, Fuse, I, Aizawa, Y
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Sprache:eng
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Zusammenfassung:Acute GVHD (aGVHD) is a serious complication after allogeneic SCT (allo-SCT). However, an adequate immunological index is not yet available for assessing its severity. We analyzed the fraction of cutaneous lymphocyte antigen (CLA) + cells in peripheral blood T and natural killer (NK) cells in 33 patients and evaluated its association with aGVHD. The CLA + T-cell fraction often increased 3–7 days before the onset of aGVHD, and the maximum percentage of CLA + T cells in grades II–IV aGVHD cases was significantly higher than that in grade 0 or I aGVHD ( P
ISSN:0268-3369
1476-5365
DOI:10.1038/bmt.2008.392