Cutaneous lymphocyte antigen-positive T cells may predict the development of acute GVHD: alterations and differences of CLA+ T- and NK-cell fractions
Acute GVHD (aGVHD) is a serious complication after allogeneic SCT (allo-SCT). However, an adequate immunological index is not yet available for assessing its severity. We analyzed the fraction of cutaneous lymphocyte antigen (CLA) + cells in peripheral blood T and natural killer (NK) cells in 33 pat...
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Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2009-06, Vol.43 (11), p.863-873 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Acute GVHD (aGVHD) is a serious complication after allogeneic SCT (allo-SCT). However, an adequate immunological index is not yet available for assessing its severity. We analyzed the fraction of cutaneous lymphocyte antigen (CLA)
+
cells in peripheral blood T and natural killer (NK) cells in 33 patients and evaluated its association with aGVHD. The CLA
+
T-cell fraction often increased 3–7 days before the onset of aGVHD, and the maximum percentage of CLA
+
T cells in grades II–IV aGVHD cases was significantly higher than that in grade 0 or I aGVHD (
P |
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ISSN: | 0268-3369 1476-5365 |
DOI: | 10.1038/bmt.2008.392 |