An Asymmetric Synthesis of Both Enantiomers of the Indole Alkaloid Deplancheine

We report a novel, facile and asymmetric approach to both enantiomers of the indole alkaloid deplancheine from a readily available, nonracemic chiral template. The natural product and its antipode are isolated with >95% ee.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2005-01, Vol.70 (1), p.357-359
Hauptverfasser:	Allin, Steven M, Thomas, Christopher I, Doyle, Kevin, Elsegood, Mark R. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alstonia - chemistry Catalysis Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Indole Alkaloids - chemical synthesis Molecular Structure Nuclear Magnetic Resonance, Biomolecular Organic chemistry Preparations and properties Stereoisomerism
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Beschreibung
Zusammenfassung:	We report a novel, facile and asymmetric approach to both enantiomers of the indole alkaloid deplancheine from a readily available, nonracemic chiral template. The natural product and its antipode are isolated with >95% ee.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo040245k