Palladium‐Catalyzed Tandem Alkenyl and Aryl CN Bond Formation: A Cascade N‐Annulation Route to 1‐Functionalized Indoles

Palladium‐Catalyzed Tandem Alkenyl and Aryl CN Bond Formation: A Cascade N‐Annulation Route to 1‐Functionalized Indoles

A single tandem operation allows rapid access to a variety of substituted N‐functionalized indoles. The nitrogen atom of the indole nucleus is incorporated through Pd‐catalyzed aryl and alkenyl CN bond‐forming reactions (see scheme; dba=dibenzylideneacetone). Amine, aniline, amide, carbamate, and s...

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Veröffentlicht in:Angewandte Chemie International Edition 2005-01, Vol.44 (3), p.403-406
Hauptverfasser: Willis, Michael C., Brace, Gareth N., Holmes, Ian P.
Format: Artikel
Sprache:eng
Schlagworte:
amination
Carbon - chemistry
cascade reactions
Catalysis
indoles
Indoles - chemistry
Nitrogen - chemistry
nitrogen heterocycles
palladium
Palladium - chemistry
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Zusammenfassung:A single tandem operation allows rapid access to a variety of substituted N‐functionalized indoles. The nitrogen atom of the indole nucleus is incorporated through Pd‐catalyzed aryl and alkenyl CN bond‐forming reactions (see scheme; dba=dibenzylideneacetone). Amine, aniline, amide, carbamate, and sulfonamide functional groups can be introduced efficiently.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200461598