Prevention of left ventricular remodeling by long-term corticosteroid therapy in patients with cardiac sarcoidosis

Forty-three patients with cardiac sarcoidosis were studied echocardiographically before and after (mean follow-up 88 months) steroid therapy to determine the effectiveness of corticosteroids to prevent left ventricular (LV) remodeling and improve LV contractility. In patients with initial LV ejectio...

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Veröffentlicht in:	The American journal of cardiology 2005, Vol.95 (1), p.143-146
Hauptverfasser:	Chiu, Chiung-Zuan, Nakatani, Satoshi, Zhang, Guican, Tachibana, Teruo, Ohmori, Fumio, Yamagishi, Masakazu, Kitakaze, Masafumi, Tomoike, Hitonobu, Miyatake, Kunio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cardiology Cardiology. Vascular system Cardiomyopathies - complications Cardiomyopathies - drug therapy Drug therapy Female Follow-Up Studies Glucocorticoids - pharmacology Glucocorticoids - therapeutic use Humans Long term Male Medical sciences Middle Aged Pharmacology. Drug treatments Prednisolone - pharmacology Prednisolone - therapeutic use Retrospective Studies Sarcoidosis - complications Sarcoidosis - drug therapy Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Steroids Time Factors Ventricular Remodeling - drug effects
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Zusammenfassung:	Forty-three patients with cardiac sarcoidosis were studied echocardiographically before and after (mean follow-up 88 months) steroid therapy to determine the effectiveness of corticosteroids to prevent left ventricular (LV) remodeling and improve LV contractility. In patients with initial LV ejection fractions (LVEFs) ≥55%, long-term steroid therapy showed preventive effects for LV remodeling and LV function. Patients with LVEF
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2004.08.083