Terminalia arjuna (Roxb.) protects rabbit heart against ischemic-reperfusion injury: role of antioxidant enzymes and heat shock protein

The bark of Terminalia arjuna Roxb. (TA) is widely recommended for the treatment of ischemic heart disease (IHD) in Indian system of medicine. Oral administration of TA for 12 weeks in rabbits caused augmentation of myocardial antioxidants; superoxide dismutase (SOD), catalase (CAT) and glutathione...

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Veröffentlicht in:	Journal of ethnopharmacology 2005-01, Vol.96 (3), p.403-409
Hauptverfasser:	Gauthaman, K., Banerjee, S.K., Dinda, A.K., Ghosh, C.C., Maulik, S.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antioxidants Antioxidants - metabolism bark Biological and medical sciences Blotting, Western cardioprotective effect Catalase - metabolism Combretaceae Endogenous antioxidant Female General pharmacology Glutathione - metabolism Heart Rate - drug effects heat shock protein 72 (HSP72) heat shock proteins Heat-Shock Proteins - metabolism histopathology HSP72 HSP72 Heat-Shock Proteins Indian traditional medicine Ischemic-Reperfusion Injury Male Medical sciences medicinal plants myocardial ischemia myocardium Oxidative Stress - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Bark - chemistry Plant Extracts - therapeutic use powders Rabbit Rabbits Reperfusion Injury - metabolism Reperfusion Injury - prevention & control Superoxide Dismutase - metabolism Terminalia arjuna traditional medicine
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Zusammenfassung:	The bark of Terminalia arjuna Roxb. (TA) is widely recommended for the treatment of ischemic heart disease (IHD) in Indian system of medicine. Oral administration of TA for 12 weeks in rabbits caused augmentation of myocardial antioxidants; superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) along with induction of heat shock protein72 (HSP72). In vivo ischemic-reperfusion injury induced oxidative stress, tissue injury of heart and haemodynamic effects were prevented in the TA treated rabbit hearts. The study provides scientific basis for the putative therapeutic effect of TA in ischemic heart disease.
ISSN:	0378-8741 1872-7573
DOI:	10.1016/j.jep.2004.08.040