Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects

BACKGROUND: Obesity is associated with insulin resistance and premature atherosclerosis. The human adipose tissue produce several adipokines including monocyte chemoattractant protein (MCP)-1, associated with cardiovascular disease and found to be involved in the pathogenesis of atherosclerosis in v...

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Veröffentlicht in:	International Journal of Obesity 2005-01, Vol.29 (1), p.146-150
Hauptverfasser:	Christiansen, T, Richelsen, B, Bruun, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - chemistry Adipocytes - metabolism Adipose tissue Adult Antigens, CD - analysis Antigens, Differentiation, Myelomonocytic - analysis Biological and medical sciences Biomarkers - analysis Body Constitution Cardiovascular diseases Cells, Cultured Chemokine CCL2 - biosynthesis Chemokine CCL2 - blood Chemokine CCL2 - genetics Epidemiology Female Health Promotion and Disease Prevention Humans Internal Medicine Leptin - blood Leptin - genetics Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Obesity Obesity, Morbid - immunology Obesity, Morbid - metabolism Obesity, Morbid - therapy Public Health RNA, Messenger - analysis short-communication Weight Loss
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Zusammenfassung:	BACKGROUND: Obesity is associated with insulin resistance and premature atherosclerosis. The human adipose tissue produce several adipokines including monocyte chemoattractant protein (MCP)-1, associated with cardiovascular disease and found to be involved in the pathogenesis of atherosclerosis in vitro . OBJECTIVE: (1) To compare mRNA levels of MCP-1, leptin and a macrophage-specific marker (CD68) in isolated adipocytes vs stromal–vascular (SV) cells, (2) to compare mRNA levels of MCP-1 in human adipose tissue to circulating MCP-1 and adiposity (eg BMI: kg/m 2 ) and (3) investigate the effect of weight loss in obese subjects on circulating MCP-1 and leptin. RESULTS: (1) MCP-1 and CD68 mRNA levels in isolated adipocytes vs SV cells were 17% ( P
ISSN:	0307-0565 1476-5497
DOI:	10.1038/sj.ijo.0802839