Preparation of 100 nm diameter unilamellar vesicles containing zinc phthalocyanine and cholesterol for use in photodynamic therapy
An efficient (89–95% yield) and low-cost procedure to prepare unilamellar vesicles was used to incorporate zinc phthalocyanine (ZnPc), a model compound used as a phototherapeutic agent in studies aiming the use of unilamellar vesicles as delivery system for photodynamic therapy (PDT). ZnPc was incor...
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| Veröffentlicht in: | Chemistry and physics of lipids 2005, Vol.133 (1), p.69-78 |
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| container_title | Chemistry and physics of lipids |
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| creator | Oliveira, Carlos A.de Machado, Antonio E.H. Pessine, Francisco B.T. |
| description | An efficient (89–95% yield) and low-cost procedure to prepare unilamellar vesicles was used to incorporate zinc phthalocyanine (ZnPc), a model compound used as a phototherapeutic agent in studies aiming the use of unilamellar vesicles as delivery system for photodynamic therapy (PDT). ZnPc was incorporated in the presence or absence of cholesterol (CHOL), which improved the stability of the delivery system. The net vesicles present a mean diameter around 1000
nm, whereas in the presence of CHOL, CHOL and ZnPc, or only ZnPc, a drastic reduction in its diameter, varying between 100 and 150
nm, was observed. The incorporation of only ZnPc also results in a considerable reduction in the diameter of the liposomes suggests that ZnPc, due to its high hidrophobicity, must share the same microenvironment occupied by CHOL molecules. |
| doi_str_mv | 10.1016/j.chemphyslip.2004.09.010 |
| format | Article |
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nm, was observed. The incorporation of only ZnPc also results in a considerable reduction in the diameter of the liposomes suggests that ZnPc, due to its high hidrophobicity, must share the same microenvironment occupied by CHOL molecules.</description><subject>Cholesterol</subject><subject>Cholesterol - chemistry</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems - instrumentation</subject><subject>Indoles - chemistry</subject><subject>Liposomes</subject><subject>Microscopy, Electron, Transmission</subject><subject>Organometallic Compounds - chemistry</subject><subject>Particle Size</subject><subject>PDT</subject><subject>Photochemotherapy - instrumentation</subject><subject>Zinc phthalocyanine</subject><issn>0009-3084</issn><issn>1873-2941</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkU2r1TAQhoMo3uPVvyBx46510iZts5SDX3BBF7oOc5KpzaFNatJzoS795eZwryCzmA8eXmbmZeyNgFqA6N6dazvRsk57nv1aNwCyBl2DgCfsIIa-rRotxVN2AABdtTDIG_Yi53NpQSnxnN0IpQbdNP2B_fmWaMWEm4-Bx5ELAB4W7jwutFHil-DnUs4zJn5P2duZMrcxbOiDDz_5bx8sX6dtwjnaHcuMOAbH7RQLWRTizMdYdDJxHwoZt-j2gIu3fJso4bq_ZM9GnDO9esy37MfHD9-Pn6u7r5--HN_fVdR0eqsUSt010mkFXTmZ-lYoIeVJyLY_jdBJtLpzI4JzODZqUIPocaCm705aDY7aW_b2QXdN8delLGcWn-31tEDxkk3Xt7JEW8DXj-DltJAza_ILpt38-1oBjg8AlXXvPSWTradgyflEdjMueiPAXL0yZ_OfV-bqlQFtilftXyrdjGA</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Oliveira, Carlos A.de</creator><creator>Machado, Antonio E.H.</creator><creator>Pessine, Francisco B.T.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>Preparation of 100 nm diameter unilamellar vesicles containing zinc phthalocyanine and cholesterol for use in photodynamic therapy</title><author>Oliveira, Carlos A.de ; Machado, Antonio E.H. ; Pessine, Francisco B.T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e269t-5a49624d9506200e7315144b1437bf064ac96dfa0ddaf2585817a8e276b958de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Cholesterol</topic><topic>Cholesterol - chemistry</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems - instrumentation</topic><topic>Indoles - chemistry</topic><topic>Liposomes</topic><topic>Microscopy, Electron, Transmission</topic><topic>Organometallic Compounds - chemistry</topic><topic>Particle Size</topic><topic>PDT</topic><topic>Photochemotherapy - instrumentation</topic><topic>Zinc phthalocyanine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oliveira, Carlos A.de</creatorcontrib><creatorcontrib>Machado, Antonio E.H.</creatorcontrib><creatorcontrib>Pessine, Francisco B.T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry and physics of lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliveira, Carlos A.de</au><au>Machado, Antonio E.H.</au><au>Pessine, Francisco B.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of 100 nm diameter unilamellar vesicles containing zinc phthalocyanine and cholesterol for use in photodynamic therapy</atitle><jtitle>Chemistry and physics of lipids</jtitle><addtitle>Chem Phys Lipids</addtitle><date>2005</date><risdate>2005</risdate><volume>133</volume><issue>1</issue><spage>69</spage><epage>78</epage><pages>69-78</pages><issn>0009-3084</issn><eissn>1873-2941</eissn><abstract>An efficient (89–95% yield) and low-cost procedure to prepare unilamellar vesicles was used to incorporate zinc phthalocyanine (ZnPc), a model compound used as a phototherapeutic agent in studies aiming the use of unilamellar vesicles as delivery system for photodynamic therapy (PDT). ZnPc was incorporated in the presence or absence of cholesterol (CHOL), which improved the stability of the delivery system. The net vesicles present a mean diameter around 1000
nm, whereas in the presence of CHOL, CHOL and ZnPc, or only ZnPc, a drastic reduction in its diameter, varying between 100 and 150
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| fulltext | fulltext |
| identifier | ISSN: 0009-3084 |
| ispartof | Chemistry and physics of lipids, 2005, Vol.133 (1), p.69-78 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Cholesterol Cholesterol - chemistry Drug delivery Drug Delivery Systems - instrumentation Indoles - chemistry Liposomes Microscopy, Electron, Transmission Organometallic Compounds - chemistry Particle Size PDT Photochemotherapy - instrumentation Zinc phthalocyanine |
| title | Preparation of 100 nm diameter unilamellar vesicles containing zinc phthalocyanine and cholesterol for use in photodynamic therapy |
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