Dendritic cell-mediated T cell polarization
Effective defense against diverse types of micro-organisms that invade our body requires specialized classes of antigen-specific immune responses initiated and maintained by distinct subsets of effector CD4(+) T helper (Th) cells. Excessive or detrimental (e.g., autoimmune) responses by effector T c...
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| Veröffentlicht in: | Seminars in immunopathology 2005, Vol.26 (3), p.289-307 |
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| container_title | Seminars in immunopathology |
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| creator | DE JONG, Esther C SMITS, Hermelijn H KAPSENBERG, Martien L |
| description | Effective defense against diverse types of micro-organisms that invade our body requires specialized classes of antigen-specific immune responses initiated and maintained by distinct subsets of effector CD4(+) T helper (Th) cells. Excessive or detrimental (e.g., autoimmune) responses by effector T cells are controlled by regulatory T cells. The optimal balance in the development of the different types of effector and regulatory Th cells is orchestrated by dendritic cells (DC). This review discusses the way DC adapt the T cell response to the type of pathogen, focusing on the tools that DC use in this management of the T cell response. |
| doi_str_mv | 10.1007/s00281-004-0167-1 |
| format | Article |
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| subjects | Animals Antigens, CD - immunology B7-1 Antigen - immunology B7-2 Antigen Biological and medical sciences Dendritic Cells - classification Dendritic Cells - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunopathology Interferon Type I - immunology Interleukin-10 - immunology Interleukin-12 - immunology Interleukin-18 - immunology Interleukin-4 - immunology Medical sciences Membrane Glycoproteins - immunology Models, Immunological OX40 Ligand Signal Transduction T-Lymphocytes, Helper-Inducer - classification T-Lymphocytes, Helper-Inducer - immunology Th1 Cells - immunology Th2 Cells - immunology |
| title | Dendritic cell-mediated T cell polarization |
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