Dendritic cell-mediated T cell polarization

Effective defense against diverse types of micro-organisms that invade our body requires specialized classes of antigen-specific immune responses initiated and maintained by distinct subsets of effector CD4(+) T helper (Th) cells. Excessive or detrimental (e.g., autoimmune) responses by effector T c...

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Veröffentlicht in:Seminars in immunopathology 2005, Vol.26 (3), p.289-307
Hauptverfasser: DE JONG, Esther C, SMITS, Hermelijn H, KAPSENBERG, Martien L
Format: Artikel
Sprache:eng
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Zusammenfassung:Effective defense against diverse types of micro-organisms that invade our body requires specialized classes of antigen-specific immune responses initiated and maintained by distinct subsets of effector CD4(+) T helper (Th) cells. Excessive or detrimental (e.g., autoimmune) responses by effector T cells are controlled by regulatory T cells. The optimal balance in the development of the different types of effector and regulatory Th cells is orchestrated by dendritic cells (DC). This review discusses the way DC adapt the T cell response to the type of pathogen, focusing on the tools that DC use in this management of the T cell response.
ISSN:0344-4325
1863-2297
1432-2196
1863-2300
DOI:10.1007/s00281-004-0167-1