Smallpox Vaccine Does Not Protect Macaques with AIDS from a Lethal Monkeypox Virus Challenge

It is unknown whether smallpox vaccination would protect human immunodeficiency virus type 1 (HIV-1)-infected individuals, because helper CD4+ cells, the targets of HIV-1 infection, are necessary for the induction of both adaptive CD8+ cell and B cell responses. We have addressed this question in ma...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of infectious diseases 2005-02, Vol.191 (3), p.372-381
Hauptverfasser:	Smith, Yvette Edghill, Bray, Mike, Whitehouse, Chris A., Miller, David, Mucker, Eric, Manischewitz, Jody, King, Lisa R., Guroff, Marjorie Robert, Hryniewicz, Anna, Venzon, David, Meseda, Clement, Weir, Jerry, Nalca, Aysegul, Livingston, Virginia, Wells, Jay, Lewis, Mark G., Huggins, John, Zwiers, Susan H., Golding, Hana, Franchini, Genoveffa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Viral - blood Antibodies, Viral - immunology Applied microbiology Biological and medical sciences CD4 Lymphocyte Count Fundamental and applied biological sciences. Psychology HIV/AIDS Human viral diseases Immunization Immunocompromised Host Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin M - blood Immunoglobulin M - immunology Infections Infectious diseases Lesions Macaca mulatta Medical sciences Microbiology Miscellaneous Monkeypox Monkeypox virus Monkeypox virus - pathogenicity Mpox (monkeypox) - mortality Mpox (monkeypox) - prevention & control Neutralization Tests Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - mortality Simian Acquired Immunodeficiency Syndrome - virology Smallpox Smallpox Vaccine - administration & dosage Smallpox Vaccine - immunology Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Attenuated - immunology Vaccinia Vaccinia virus Vaccinia virus - immunology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	It is unknown whether smallpox vaccination would protect human immunodeficiency virus type 1 (HIV-1)-infected individuals, because helper CD4+ cells, the targets of HIV-1 infection, are necessary for the induction of both adaptive CD8+ cell and B cell responses. We have addressed this question in macaques and have demonstrated that, although smallpox vaccination is safe in immunodeficient macaques when it is preceded by immunization with highly attenuated vaccinia strains, the macaques were not protected against lethal monkeypox virus challenge if their CD4+ cell count was
ISSN:	0022-1899 1537-6613
DOI:	10.1086/427265