Retinal nerve fiber layer evaluation by optical coherence tomography in Leber's hereditary optic neuropathy
To study retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (StratusOCT) in patients with Leber's hereditary optic neuropathy (LHON). Cross-sectional study. Thirty-eight patients with LHON were analyzed and compared with an age-matched control group of 75 patients. Patie...
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| Veröffentlicht in: | Ophthalmology (Rochester, Minn.) Minn.), 2005, Vol.112 (1), p.120-126 |
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| creator | Barboni, Piero Savini, Giacomo Valentino, Maria Lucia Montagna, Pasquale Cortelli, Pietro De Negri, Anna Maria Sadun, Federico Bianchi, Stefania Longanesi, Lora Zanini, Maurizio de Vivo, Antonello Carelli, Valerio |
| description | To study retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (StratusOCT) in patients with Leber's hereditary optic neuropathy (LHON).
Cross-sectional study.
Thirty-eight patients with LHON were analyzed and compared with an age-matched control group of 75 patients. Patients with LHON were classified as having early LHON (E-LHON, n = 8) when the duration of the disease was shorter than 6 months and atrophic LHON (A-LHON, n = 30) when the duration was longer than 6 months.
The fast RNFL thickness (3.4) scan acquisition protocol was used.
Retinal nerve fiber layer thickness as measured by StratusOCT.
Compared with the control group, eyes with E-LHON showed a thicker RNFL in the 360° average measurement (
P |
| doi_str_mv | 10.1016/j.ophtha.2004.06.034 |
| format | Article |
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Cross-sectional study.
Thirty-eight patients with LHON were analyzed and compared with an age-matched control group of 75 patients. Patients with LHON were classified as having early LHON (E-LHON, n = 8) when the duration of the disease was shorter than 6 months and atrophic LHON (A-LHON, n = 30) when the duration was longer than 6 months.
The fast RNFL thickness (3.4) scan acquisition protocol was used.
Retinal nerve fiber layer thickness as measured by StratusOCT.
Compared with the control group, eyes with E-LHON showed a thicker RNFL in the 360° average measurement (
P<0.01) and in the superior (
P<0.01), nasal (
P<0.05), and inferior quadrants (
P<0.05); no significant changes were detected in the temporal quadrant. Eyes with A-LHON revealed a thinner RNFL in all measurements (
P<0.001); the fibers of the nasal quadrant showed the lowest amount of reduction (38% vs. 42%–49.8% in the other quadrants). In cases with A-LHON and visual recovery, RNFL was significantly thicker in all measurements (
P<0.001), except the temporal quadrant, with respect to A-LHON without visual recovery.
On the basis of OCT data, the RNFL is thickened in E-LHON and severely thinned in A-LHON. RNFL is likely to be partially preserved in A-LHON with visual recovery. The temporal fibers (papillomacular bundle) are the first and most severely affected; the nasal fibers seem to be partially spared in the late stage of the disease.]]></description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/j.ophtha.2004.06.034</identifier><identifier>PMID: 15629831</identifier><identifier>CODEN: OPHTDG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acute Disease ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Child ; Cross-Sectional Studies ; Diagnostic Techniques, Ophthalmological ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Nerve Fibers - pathology ; Ophthalmology ; Optic Atrophy, Hereditary, Leber - diagnosis ; Optic Atrophy, Hereditary, Leber - genetics ; Retinal Ganglion Cells - pathology ; Retinopathies ; Tomography, Optical Coherence</subject><ispartof>Ophthalmology (Rochester, Minn.), 2005, Vol.112 (1), p.120-126</ispartof><rights>2005 American Academy of Ophthalmology</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-998a7a45b73027bfac6bb569e3763eddcf0167c0324d1b7b9e76e6bb6c7fc45f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016164200401125X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16431251$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15629831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barboni, Piero</creatorcontrib><creatorcontrib>Savini, Giacomo</creatorcontrib><creatorcontrib>Valentino, Maria Lucia</creatorcontrib><creatorcontrib>Montagna, Pasquale</creatorcontrib><creatorcontrib>Cortelli, Pietro</creatorcontrib><creatorcontrib>De Negri, Anna Maria</creatorcontrib><creatorcontrib>Sadun, Federico</creatorcontrib><creatorcontrib>Bianchi, Stefania</creatorcontrib><creatorcontrib>Longanesi, Lora</creatorcontrib><creatorcontrib>Zanini, Maurizio</creatorcontrib><creatorcontrib>de Vivo, Antonello</creatorcontrib><creatorcontrib>Carelli, Valerio</creatorcontrib><title>Retinal nerve fiber layer evaluation by optical coherence tomography in Leber's hereditary optic neuropathy</title><title>Ophthalmology (Rochester, Minn.)</title><addtitle>Ophthalmology</addtitle><description><![CDATA[To study retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (StratusOCT) in patients with Leber's hereditary optic neuropathy (LHON).
Cross-sectional study.
Thirty-eight patients with LHON were analyzed and compared with an age-matched control group of 75 patients. Patients with LHON were classified as having early LHON (E-LHON, n = 8) when the duration of the disease was shorter than 6 months and atrophic LHON (A-LHON, n = 30) when the duration was longer than 6 months.
The fast RNFL thickness (3.4) scan acquisition protocol was used.
Retinal nerve fiber layer thickness as measured by StratusOCT.
Compared with the control group, eyes with E-LHON showed a thicker RNFL in the 360° average measurement (
P<0.01) and in the superior (
P<0.01), nasal (
P<0.05), and inferior quadrants (
P<0.05); no significant changes were detected in the temporal quadrant. Eyes with A-LHON revealed a thinner RNFL in all measurements (
P<0.001); the fibers of the nasal quadrant showed the lowest amount of reduction (38% vs. 42%–49.8% in the other quadrants). In cases with A-LHON and visual recovery, RNFL was significantly thicker in all measurements (
P<0.001), except the temporal quadrant, with respect to A-LHON without visual recovery.
On the basis of OCT data, the RNFL is thickened in E-LHON and severely thinned in A-LHON. RNFL is likely to be partially preserved in A-LHON with visual recovery. The temporal fibers (papillomacular bundle) are the first and most severely affected; the nasal fibers seem to be partially spared in the late stage of the disease.]]></description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Diagnostic Techniques, Ophthalmological</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nerve Fibers - pathology</subject><subject>Ophthalmology</subject><subject>Optic Atrophy, Hereditary, Leber - diagnosis</subject><subject>Optic Atrophy, Hereditary, Leber - genetics</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Retinopathies</subject><subject>Tomography, Optical Coherence</subject><issn>0161-6420</issn><issn>1549-4713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAURUVpaSZp_yAEbdqu7EiWLI03gRDatDBQKOlaSPJzrInHciR5YP6-MmPIrpunxTv38nQQuqakpISK233ppz71uqwI4SURJWH8HdrQmjcFl5S9R5uM0ULwilygyxj3hBAhGP-ILmgtqmbL6Aa9_IHkRj3gEcIRcOcMBDzoU55w1MOsk_MjNifsp-Rs5qzvIcBoASd_8M9BT_0JuxHvICe_RbxsW5d0WCO5eA5-0qk_fUIfOj1E-Ly-V-jvj-9PDz-L3e_HXw_3u8KyhqSiabZaal4byUglTaetMKYWDTApGLSt7fK_pCWs4i010jQgBWREWNlZXnfsCn09907Bv84Qkzq4aGEY9Ah-jkpIxpot5xnkZ9AGH2OATk3BHfLpihK1SFZ7dZasFsmKCJUl59jN2j-bA7RvodVqBr6sgI7ZWRf0aF184wRntKoX7u7MQbZxdBBUtG5x27oANqnWu_9f8g-SQJ7q</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Barboni, Piero</creator><creator>Savini, Giacomo</creator><creator>Valentino, Maria Lucia</creator><creator>Montagna, Pasquale</creator><creator>Cortelli, Pietro</creator><creator>De Negri, Anna Maria</creator><creator>Sadun, Federico</creator><creator>Bianchi, Stefania</creator><creator>Longanesi, Lora</creator><creator>Zanini, Maurizio</creator><creator>de Vivo, Antonello</creator><creator>Carelli, Valerio</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>Retinal nerve fiber layer evaluation by optical coherence tomography in Leber's hereditary optic neuropathy</title><author>Barboni, Piero ; Savini, Giacomo ; Valentino, Maria Lucia ; Montagna, Pasquale ; Cortelli, Pietro ; De Negri, Anna Maria ; Sadun, Federico ; Bianchi, Stefania ; Longanesi, Lora ; Zanini, Maurizio ; de Vivo, Antonello ; Carelli, Valerio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-998a7a45b73027bfac6bb569e3763eddcf0167c0324d1b7b9e76e6bb6c7fc45f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Diagnostic Techniques, Ophthalmological</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nerve Fibers - pathology</topic><topic>Ophthalmology</topic><topic>Optic Atrophy, Hereditary, Leber - diagnosis</topic><topic>Optic Atrophy, Hereditary, Leber - genetics</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Retinopathies</topic><topic>Tomography, Optical Coherence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barboni, Piero</creatorcontrib><creatorcontrib>Savini, Giacomo</creatorcontrib><creatorcontrib>Valentino, Maria Lucia</creatorcontrib><creatorcontrib>Montagna, Pasquale</creatorcontrib><creatorcontrib>Cortelli, Pietro</creatorcontrib><creatorcontrib>De Negri, Anna Maria</creatorcontrib><creatorcontrib>Sadun, Federico</creatorcontrib><creatorcontrib>Bianchi, Stefania</creatorcontrib><creatorcontrib>Longanesi, Lora</creatorcontrib><creatorcontrib>Zanini, Maurizio</creatorcontrib><creatorcontrib>de Vivo, Antonello</creatorcontrib><creatorcontrib>Carelli, Valerio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmology (Rochester, Minn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barboni, Piero</au><au>Savini, Giacomo</au><au>Valentino, Maria Lucia</au><au>Montagna, Pasquale</au><au>Cortelli, Pietro</au><au>De Negri, Anna Maria</au><au>Sadun, Federico</au><au>Bianchi, Stefania</au><au>Longanesi, Lora</au><au>Zanini, Maurizio</au><au>de Vivo, Antonello</au><au>Carelli, Valerio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal nerve fiber layer evaluation by optical coherence tomography in Leber's hereditary optic neuropathy</atitle><jtitle>Ophthalmology (Rochester, Minn.)</jtitle><addtitle>Ophthalmology</addtitle><date>2005</date><risdate>2005</risdate><volume>112</volume><issue>1</issue><spage>120</spage><epage>126</epage><pages>120-126</pages><issn>0161-6420</issn><eissn>1549-4713</eissn><coden>OPHTDG</coden><abstract><![CDATA[To study retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (StratusOCT) in patients with Leber's hereditary optic neuropathy (LHON).
Cross-sectional study.
Thirty-eight patients with LHON were analyzed and compared with an age-matched control group of 75 patients. Patients with LHON were classified as having early LHON (E-LHON, n = 8) when the duration of the disease was shorter than 6 months and atrophic LHON (A-LHON, n = 30) when the duration was longer than 6 months.
The fast RNFL thickness (3.4) scan acquisition protocol was used.
Retinal nerve fiber layer thickness as measured by StratusOCT.
Compared with the control group, eyes with E-LHON showed a thicker RNFL in the 360° average measurement (
P<0.01) and in the superior (
P<0.01), nasal (
P<0.05), and inferior quadrants (
P<0.05); no significant changes were detected in the temporal quadrant. Eyes with A-LHON revealed a thinner RNFL in all measurements (
P<0.001); the fibers of the nasal quadrant showed the lowest amount of reduction (38% vs. 42%–49.8% in the other quadrants). In cases with A-LHON and visual recovery, RNFL was significantly thicker in all measurements (
P<0.001), except the temporal quadrant, with respect to A-LHON without visual recovery.
On the basis of OCT data, the RNFL is thickened in E-LHON and severely thinned in A-LHON. RNFL is likely to be partially preserved in A-LHON with visual recovery. The temporal fibers (papillomacular bundle) are the first and most severely affected; the nasal fibers seem to be partially spared in the late stage of the disease.]]></abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15629831</pmid><doi>10.1016/j.ophtha.2004.06.034</doi><tpages>7</tpages></addata></record> |
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| ispartof | Ophthalmology (Rochester, Minn.), 2005, Vol.112 (1), p.120-126 |
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| subjects | Acute Disease Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Child Cross-Sectional Studies Diagnostic Techniques, Ophthalmological Female Humans Male Medical sciences Middle Aged Nerve Fibers - pathology Ophthalmology Optic Atrophy, Hereditary, Leber - diagnosis Optic Atrophy, Hereditary, Leber - genetics Retinal Ganglion Cells - pathology Retinopathies Tomography, Optical Coherence |
| title | Retinal nerve fiber layer evaluation by optical coherence tomography in Leber's hereditary optic neuropathy |
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