Retinal nerve fiber layer evaluation by optical coherence tomography in Leber's hereditary optic neuropathy

To study retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (StratusOCT) in patients with Leber's hereditary optic neuropathy (LHON). Cross-sectional study. Thirty-eight patients with LHON were analyzed and compared with an age-matched control group of 75 patients. Patients with LHON were classified as having early LHON (E-LHON, n = 8) when the duration of the disease was shorter than 6 months and atrophic LHON (A-LHON, n = 30) when the duration was longer than 6 months. The fast RNFL thickness (3.4) scan acquisition protocol was used. Retinal nerve fiber layer thickness as measured by StratusOCT. Compared with the control group, eyes with E-LHON showed a thicker RNFL in the 360° average measurement ( P