Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors

Substituted benzimidazoles were profiled as inhibitors of kinesin spindle protein (KSP), an increasingly important target for the development of anticancer drugs. This series demonstrated the monoastral phenotypic response and was found to be active in both enzymatic and cellular-based assays.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-07, Vol.19 (13), p.3405-3409
Hauptverfasser:	Lahue, Brian R., Ma, Yao, Shipps, Gerald W., Seghezzi, Wolfgang, Herbst, Ronald
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Benzimidazole Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Benzimidazoles - pharmacology Biological and medical sciences Caco-2 Cells Cancer Cell Line Cooperative Cytochrome P-450 Enzyme System - metabolism Cytokinetics Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General aspects hKSP Humans Ispinesib Kinesin - antagonists & inhibitors Kinesin - metabolism KSP Medical sciences Monoaster Pharmacology. Drug treatments Rats Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Substituted benzimidazoles were profiled as inhibitors of kinesin spindle protein (KSP), an increasingly important target for the development of anticancer drugs. This series demonstrated the monoastral phenotypic response and was found to be active in both enzymatic and cellular-based assays.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2009.05.040