Absence of acute effects of angiotensin II on atrial electrophysiology in humans

In differing animal models, angiotensin-converting enzyme inhibition or angiotensin II (AII) antagonists has been shown to prevent both acute (hours) (2) electrical remodeling and chronic (weeks) structural remodeling (3). Clinical studies have suggested that AII antagonists or angiotensin-convertin...

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Veröffentlicht in:	Journal of the American College of Cardiology 2005-01, Vol.45 (1), p.154-156
Hauptverfasser:	Kistler, Peter M., Davidson, Neil C., Sanders, Prashanthan, Fynn, Simon P., Stevenson, Irene H., Spence, Steven J., Vohra, Jitendra K., Sparks, Paul B., Kalman, Jonathan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiotensin II - pharmacology Atrial Function - drug effects Atrial Function - physiology Cardiology Drug therapy Electrophysiologic Techniques, Cardiac Enzymes Female Heart Atria - drug effects Heart failure Hemodynamics - drug effects Humans Male Renin-Angiotensin System - physiology Vasoconstrictor Agents - pharmacology
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Beschreibung
Zusammenfassung:	In differing animal models, angiotensin-converting enzyme inhibition or angiotensin II (AII) antagonists has been shown to prevent both acute (hours) (2) electrical remodeling and chronic (weeks) structural remodeling (3). Clinical studies have suggested that AII antagonists or angiotensin-converting enzyme inhibitors may be effective in reducing AF in patients with heart failure or after cardioversion (10,11).
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2004.10.002