Apoptosis in the Colonic Crypt, Colorectal Adenomata, and Manipulation by Chemoprevention

This review discusses the biology and the methods of assessment of apoptosis, of which, the monoclonal antibody M30 would seem to be the most useful; the role of apoptosis in the etiology of colorectal cancer; and its use as a marker to monitor the beneficial effects of chemopreventative interventio...

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Veröffentlicht in:	Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2009-06, Vol.18 (6), p.1680-1687
Hauptverfasser:	WEST, Nicholas J, COURTNEY, Edward D. J, POULLIS, Andrew P, LEICESTER, Roger J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - metabolism Adenoma - pathology Adenoma - prevention & control Animals Antibodies, Monoclonal Apoptosis - physiology Biological and medical sciences Biomarkers, Tumor - analysis Chemoprevention - methods Clinical Trials as Topic Colon - metabolism Colon - pathology Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Colorectal Neoplasms - prevention & control Humans Medical sciences Mice Precancerous Conditions - metabolism Precancerous Conditions - pathology Precancerous Conditions - prevention & control Tumors
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Beschreibung
Zusammenfassung:	This review discusses the biology and the methods of assessment of apoptosis, of which, the monoclonal antibody M30 would seem to be the most useful; the role of apoptosis in the etiology of colorectal cancer; and its use as a marker to monitor the beneficial effects of chemopreventative interventions to reduce the development of colorectal cancer within the context of clinical trials. (Cancer Epidemiol Biomarkers Prev 2009;18(6):1680–7)
ISSN:	1055-9965 1538-7755
DOI:	10.1158/1055-9965.EPI-09-0006