Serratezomines D and E, new Lycopodium alkaloids from Lycopodium serratum var. serratum

Two new Lycopodium alkaloids, serratezomines D ( 1) and E ( 2), were isolated from the club moss Lycopodium serratum var. serratum. Serratezomine D ( 1) is a new lucidine-type alkaloid, while serratezomine E ( 2) is a new phlegmarane-type alkaloid. The structures and relative stereochemistry of 1 an...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-07, Vol.19 (13), p.3577-3580
Hauptverfasser:	Kubota, Takaaki, Yahata, Hiroko, Yamamoto, Sunao, Hayashi, Shigeki, Shibata, Toshiro, Kobayashi, Jun’ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - chemistry Acetylcholinesterase - metabolism Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Biological and medical sciences Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - isolation & purification Cholinesterase Inhibitors - pharmacology General pharmacology Heterocyclic Compounds, 2-Ring - chemistry Heterocyclic Compounds, 2-Ring - isolation & purification Heterocyclic Compounds, 2-Ring - pharmacology Heterocyclic Compounds, 3-Ring - chemistry Heterocyclic Compounds, 3-Ring - isolation & purification Heterocyclic Compounds, 3-Ring - pharmacology Lycopodium - chemistry Lycopodium alkaloids Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Quinolines - chemistry Quinolines - isolation & purification Quinolines - pharmacology Serratezomines D and E Stereoisomerism
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Zusammenfassung:	Two new Lycopodium alkaloids, serratezomines D ( 1) and E ( 2), were isolated from the club moss Lycopodium serratum var. serratum. Serratezomine D ( 1) is a new lucidine-type alkaloid, while serratezomine E ( 2) is a new phlegmarane-type alkaloid. The structures and relative stereochemistry of 1 and 2 were elucidated on the basis of spectroscopic data. Serratezomine D ( 1) exhibited an inhibitory activity against acetylcholinesterase.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2009.04.146