5-Amidinobenzo[ b]thiophenes as dual inhibitors of factors IXa and Xa

Syntheses and SAR studies of 5-amidinobenzo[ b]thiophene analogs provided compounds with low submicromolar factor IXa potency and equal or slightly better selectivity relative to factor Xa. Syntheses and SAR studies of 5-amidinobenzo[ b]thiophene analogs provided compounds with low submicromolar fac...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-01, Vol.15 (1), p.29-35
Hauptverfasser:	Qiao, Jennifer X., Cheng, Xuhong, Modi, Dilip P., Rossi, Karen A., Luettgen, Joseph M., Knabb, Robert M., Jadhav, Prabhakar K., Wexler, Ruth R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulant Benzo[ b]thiophene Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Factor IXa Factor IXa - antagonists & inhibitors Factor Xa Inhibitors Medical sciences Pharmacology. Drug treatments Serine Proteinase Inhibitors - chemistry Serine Proteinase Inhibitors - pharmacology Structure-Activity Relationship Thiophenes - chemistry Thiophenes - pharmacology
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Zusammenfassung:	Syntheses and SAR studies of 5-amidinobenzo[ b]thiophene analogs provided compounds with low submicromolar factor IXa potency and equal or slightly better selectivity relative to factor Xa. Syntheses and SAR studies of 5-amidinobenzo[ b]thiophene analogs provided compounds with low submicromolar factor IXa activity and equal or slightly better selectivity relative to factor Xa.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2004.10.045