Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers

A series of benzoxathiin SERAMs was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue. A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor m...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-01, Vol.15 (1), p.107-113
Hauptverfasser:	Blizzard, Timothy A., DiNinno, Frank, Morgan, Jerry D., Chen, Helen Y., Wu, Jane Y., Kim, Seongkon, Chan, Wanda, Birzin, Elizabeth T., Yang, Yi Tien, Pai, Lee-Yuh, Fitzgerald, Paula M.D., Sharma, Nandini, Li, Ying, Zhang, Zhoupeng, Hayes, Edward C., DaSilva, Carolyn A., Tang, Wei, Rohrer, Susan P., Schaeffer, James M., Hammond, Milton L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Estrogen Hormones. Endocrine system Ligands Medical sciences Models, Molecular Oxathiins - chemistry Oxathiins - pharmacology Pharmacology. Drug treatments Pyrrolidines - chemistry Receptors, Estrogen - drug effects Receptors, Estrogen - metabolism Selective Estrogen Receptor Modulators - pharmacology SERAMs SERMs
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Beschreibung
Zusammenfassung:	A series of benzoxathiin SERAMs was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue. A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2004.10.036