Thiazolidinediones may contribute to the intramyocardial lipid accumulation in diabetic myocardium: effects on cardiac function

Thiazolidinediones may contribute to the intramyocardial lipid accumulation in diabetic myocardium: effects on cardiac function

TZD-treated patients presented a reduced FS compared to non-TZD-treated patients. [...]we evidence that a close correlation exists between cardiac function and myocardial morphology in TZD-treated patients since the cardiac dysfunction was independent from the MS severity and was associated with a m...

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Veröffentlicht in:Heart (British Cardiac Society) 2009-06, Vol.95 (12), p.1020-1022
Hauptverfasser: Marfella, R, Portoghese, M, Ferraraccio, F, Siniscalchi, M, Babieri, M, Di Filippo, C, D’Amico, M, Rossi, F, Paolisso, G
Format: Artikel
Sprache:eng
Schlagworte:
Biopsy
Diabetes
Diabetes Mellitus, Type 2 - metabolism
Female
Heart attacks
Heart failure
Humans
Insulin
Lipid Metabolism - drug effects
Lipids
Male
Middle Aged
Myocardium - metabolism
PPAR gamma - agonists
Proteins
Rodents
Thiazolidinediones - pharmacology
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Zusammenfassung:TZD-treated patients presented a reduced FS compared to non-TZD-treated patients. [...]we evidence that a close correlation exists between cardiac function and myocardial morphology in TZD-treated patients since the cardiac dysfunction was independent from the MS severity and was associated with a marked cardiomyocyte lipid accumulation.
ISSN:1355-6037
1468-201X
DOI:10.1136/hrt.2009.165969