Interleukin 17 Production among Patients with American Cutaneous Leishmaniasis
Interleukin 17 (IL‐17) plays a critical role in inflammation and autoimmunity. Very little is known about IL‐17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL‐17 than do lymphocytes obtai...
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| Veröffentlicht in: | The Journal of infectious diseases 2009-07, Vol.200 (1), p.75-78 |
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| creator | Bacellar, Olívia Faria, Daniela Nascimento, Márcia Cardoso, Thiago M. Gollob, Kenneth J. Dutra, Walderez O. Scott, Phillip Carvalho, Edgar M. |
| description | Interleukin 17 (IL‐17) plays a critical role in inflammation and autoimmunity. Very little is known about IL‐17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL‐17 than do lymphocytes obtained from uninfected control subjects (P |
| doi_str_mv | 10.1086/599380 |
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Very little is known about IL‐17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL‐17 than do lymphocytes obtained from uninfected control subjects (P<.01). There was a tendency for tissue obtained from patients with mucosal leishmaniasis to contain a higher number of cells expressing IL‐17, compared with tissue obtained from patients with cutaneous leishmaniasis, and there was a direct correlation between the number of cells expressing IL‐17 and the presence of cellular inflammation at the lesion site (r2=0.86; P<.001). These data support the role of IL‐17 in the pathogenesis of the inflammatory reaction in leishmaniasis.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/599380</identifier><identifier>PMID: 19476435</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: University of Chicago Press</publisher><subject>Antigens ; Autoimmunity ; Biological and medical sciences ; Cutaneous leishmaniasis ; Cytokines ; Fundamental and applied biological sciences. Psychology ; Humans ; Infections ; Infectious diseases ; Inflammation - immunology ; Interleukin-17 - genetics ; Interleukins ; Leishmaniasis ; Leishmaniasis, Mucocutaneous - genetics ; Leishmaniasis, Mucocutaneous - immunology ; Lesions ; Lymphocyte Activation - genetics ; Lymphocyte Activation - immunology ; Lymphocytes - immunology ; Medical sciences ; Microbiology ; Parasites ; Pathogenesis ; Reference Values ; T lymphocytes ; Th1 Cells - immunology ; Tissue samples</subject><ispartof>The Journal of infectious diseases, 2009-07, Vol.200 (1), p.75-78</ispartof><rights>Copyright 2008 Infectious Diseases Society of America</rights><rights>2009 by the Infectious Diseases Society of America. All rights reserved. 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-83bc1cf9505ecd61c17e4c920e90646c4454f169d0c4793447fe78372dea71a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40255114$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40255114$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21749411$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19476435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bacellar, Olívia </creatorcontrib><creatorcontrib>Faria, Daniela </creatorcontrib><creatorcontrib>Nascimento, Márcia </creatorcontrib><creatorcontrib>Cardoso, Thiago M. </creatorcontrib><creatorcontrib>Gollob, Kenneth J. </creatorcontrib><creatorcontrib>Dutra, Walderez O. </creatorcontrib><creatorcontrib>Scott, Phillip </creatorcontrib><creatorcontrib>Carvalho, Edgar M. </creatorcontrib><title>Interleukin 17 Production among Patients with American Cutaneous Leishmaniasis</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Interleukin 17 (IL‐17) plays a critical role in inflammation and autoimmunity. Very little is known about IL‐17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL‐17 than do lymphocytes obtained from uninfected control subjects (P<.01). There was a tendency for tissue obtained from patients with mucosal leishmaniasis to contain a higher number of cells expressing IL‐17, compared with tissue obtained from patients with cutaneous leishmaniasis, and there was a direct correlation between the number of cells expressing IL‐17 and the presence of cellular inflammation at the lesion site (r2=0.86; P<.001). These data support the role of IL‐17 in the pathogenesis of the inflammatory reaction in leishmaniasis.</description><subject>Antigens</subject><subject>Autoimmunity</subject><subject>Biological and medical sciences</subject><subject>Cutaneous leishmaniasis</subject><subject>Cytokines</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Inflammation - immunology</subject><subject>Interleukin-17 - genetics</subject><subject>Interleukins</subject><subject>Leishmaniasis</subject><subject>Leishmaniasis, Mucocutaneous - genetics</subject><subject>Leishmaniasis, Mucocutaneous - immunology</subject><subject>Lesions</subject><subject>Lymphocyte Activation - genetics</subject><subject>Lymphocyte Activation - immunology</subject><subject>Lymphocytes - immunology</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Parasites</subject><subject>Pathogenesis</subject><subject>Reference Values</subject><subject>T lymphocytes</subject><subject>Th1 Cells - immunology</subject><subject>Tissue samples</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1v1DAQBmALgehS4B-AwgFuAY89tuNjtXxsYQVF9IB6sVzHoW4TZ7EdAf-eVFktXBAnH95HM-OXkMdAXwJt5CuhNW_oHbICwVUtJfC7ZEUpYzU0Wh-RBzlfU0qRS3WfHIFGJZGLFfl4GotPvZ9uQqxAVWdpbCdXwhgrO4zxW3VmS_Cx5OpHKFfVyeBTcDZW66nY6McpV1sf8tVgY7A55IfkXmf77B_t32Ny_vbN-XpTbz-9O12fbGuHQpa64ZcOXKcFFd61Ehwoj04z6jWVKB2iwA6kbqlDpTmi6rxquGKttwosPyYvlrG7NH6ffC5mCNn5vl9uMlJx2sxf_C9kwBgD_Au6NOacfGd2KQw2_TJAzW3DZml4hk_3E6fLwbd_2L7SGTzfA5ud7btkowv54Bgo1Agwu2eLG6fdv5c9Wcx1LmM6KKRMCACc83rJQy7-5yG36ea2AiXM5uuFWX_58Pni_Ws0G_4bSNikKw</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Bacellar, Olívia </creator><creator>Faria, Daniela </creator><creator>Nascimento, Márcia </creator><creator>Cardoso, Thiago M. </creator><creator>Gollob, Kenneth J. </creator><creator>Dutra, Walderez O. </creator><creator>Scott, Phillip </creator><creator>Carvalho, Edgar M. </creator><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>C1K</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Interleukin 17 Production among Patients with American Cutaneous Leishmaniasis</title><author>Bacellar, Olívia ; Faria, Daniela ; Nascimento, Márcia ; Cardoso, Thiago M. ; Gollob, Kenneth J. ; Dutra, Walderez O. ; Scott, Phillip ; Carvalho, Edgar M. </author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-83bc1cf9505ecd61c17e4c920e90646c4454f169d0c4793447fe78372dea71a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Antigens</topic><topic>Autoimmunity</topic><topic>Biological and medical sciences</topic><topic>Cutaneous leishmaniasis</topic><topic>Cytokines</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Inflammation - immunology</topic><topic>Interleukin-17 - genetics</topic><topic>Interleukins</topic><topic>Leishmaniasis</topic><topic>Leishmaniasis, Mucocutaneous - genetics</topic><topic>Leishmaniasis, Mucocutaneous - immunology</topic><topic>Lesions</topic><topic>Lymphocyte Activation - genetics</topic><topic>Lymphocyte Activation - immunology</topic><topic>Lymphocytes - immunology</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Parasites</topic><topic>Pathogenesis</topic><topic>Reference Values</topic><topic>T lymphocytes</topic><topic>Th1 Cells - immunology</topic><topic>Tissue samples</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bacellar, Olívia </creatorcontrib><creatorcontrib>Faria, Daniela </creatorcontrib><creatorcontrib>Nascimento, Márcia </creatorcontrib><creatorcontrib>Cardoso, Thiago M. </creatorcontrib><creatorcontrib>Gollob, Kenneth J. </creatorcontrib><creatorcontrib>Dutra, Walderez O. </creatorcontrib><creatorcontrib>Scott, Phillip </creatorcontrib><creatorcontrib>Carvalho, Edgar M. </creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bacellar, Olívia </au><au>Faria, Daniela </au><au>Nascimento, Márcia </au><au>Cardoso, Thiago M. </au><au>Gollob, Kenneth J. </au><au>Dutra, Walderez O. </au><au>Scott, Phillip </au><au>Carvalho, Edgar M. </au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin 17 Production among Patients with American Cutaneous Leishmaniasis</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>200</volume><issue>1</issue><spage>75</spage><epage>78</epage><pages>75-78</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Interleukin 17 (IL‐17) plays a critical role in inflammation and autoimmunity. 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| ispartof | The Journal of infectious diseases, 2009-07, Vol.200 (1), p.75-78 |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Antigens Autoimmunity Biological and medical sciences Cutaneous leishmaniasis Cytokines Fundamental and applied biological sciences. Psychology Humans Infections Infectious diseases Inflammation - immunology Interleukin-17 - genetics Interleukins Leishmaniasis Leishmaniasis, Mucocutaneous - genetics Leishmaniasis, Mucocutaneous - immunology Lesions Lymphocyte Activation - genetics Lymphocyte Activation - immunology Lymphocytes - immunology Medical sciences Microbiology Parasites Pathogenesis Reference Values T lymphocytes Th1 Cells - immunology Tissue samples |
| title | Interleukin 17 Production among Patients with American Cutaneous Leishmaniasis |
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