Direct Evidence for a Furtive State in the Degradation of Carbasalatum Calcicum

Direct Evidence for a Furtive State in the Degradation of Carbasalatum Calcicum

Blink and you will miss it! The structure of carbasalatum calcicum (CC) has been determined by synchrotron powder diffractometry. By scrutinizing crystal dissolution and nucleation, it was found that the degradation of CC in water involves acetylsalicylatum calcicum (AC) as a furtive species that qu...

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Veröffentlicht in:Angewandte Chemie International Edition 2004-05, Vol.43 (20), p.2694-2697
Hauptverfasser: Ochsenbein, Philippe, Bonin, Michel, Masson, Olivier, Loyaux, Denis, Chapuis, Gervais, Schenk, Kurt J.
Format: Artikel
Sprache:eng
Schlagworte:
Aspirin - analogs & derivatives
bridging ligands
calcium
Calcium - chemistry
Calcium Compounds - chemistry
Hydrogen Bonding
hydrogen bonds
Ligands
Microscopy
Molecular Structure
optical microscopy
Oxides - chemistry
structure elucidation
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Zusammenfassung:Blink and you will miss it! The structure of carbasalatum calcicum (CC) has been determined by synchrotron powder diffractometry. By scrutinizing crystal dissolution and nucleation, it was found that the degradation of CC in water involves acetylsalicylatum calcicum (AC) as a furtive species that quickly exchanges its acetylsalicylic acid (ASA) ligands with water (see scheme). The crystal structure of AC is also reported.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200353007