Highly Enantioselective Catalytic Alkyl Propiolate Addition to Aliphatic Aldehydes

Highly Enantioselective Catalytic Alkyl Propiolate Addition to Aliphatic Aldehydes

A novel H8BINOL-based chiral ligand (S)-3 is found to catalyze the alkyl propiolate addition to aliphatic aldehydes in the presence of ZnEt2 and Ti(O i Pr)4 at room temperature with excellent enantioselectivity (89−97% ee).

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Veröffentlicht in:Organic letters 2009-06, Vol.11 (11), p.2441-2444
Hauptverfasser: Turlington, Mark, DeBerardinis, Albert M, Pu, Lin
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel H8BINOL-based chiral ligand (S)-3 is found to catalyze the alkyl propiolate addition to aliphatic aldehydes in the presence of ZnEt2 and Ti(O i Pr)4 at room temperature with excellent enantioselectivity (89−97% ee).
ISSN:1523-7060
1523-7052
DOI:10.1021/ol900667g