Modelling and simulation in the development and use of anti-cancer agents : An underused tool?

To help identify the role of modelling and simulation in the development of anti-cancer agents, their main advantages and the obstacles to their rational use, an expert meeting was organized by COST B15. This manuscript presents a synthesis of views expressed at that meeting and indicates future dir...

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Veröffentlicht in:	Journal of pharmacokinetics and pharmacodynamics 2004-12, Vol.31 (6), p.419-440
Hauptverfasser:	ROMBOUT, Ferdinand, AARONS, Leon, VAN PEER, Achiel, KARLSSON, Mats, MAN, Anthony, MENTRE, France, NYGREN, Peter, RACINE, Amy, SCHAEFER, Hans, STEIMER, Jean-Louis, TROCONIZ, Inaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biological and medical sciences Cancer Capecitabine Chemotherapy Clinical Trials as Topic Computer Simulation Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Drug Administration Schedule Drug Design Fluorouracil - analogs & derivatives Humans Medical sciences Models, Biological Pharmaceutical industry Pharmacology. Drug treatments Product Surveillance, Postmarketing Quality of Life Taxoids - therapeutic use Vinblastine - analogs & derivatives Vinblastine - therapeutic use
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Zusammenfassung:	To help identify the role of modelling and simulation in the development of anti-cancer agents, their main advantages and the obstacles to their rational use, an expert meeting was organized by COST B15. This manuscript presents a synthesis of views expressed at that meeting and indicates future directions. The manuscript also shows some examples where modelling and simulation have proven to be of relevant value in the drug development process for anti-cancer agents.
ISSN:	1567-567X 1573-8744
DOI:	10.1007/s10928-005-5910-2