Vascular Endothelial Growth Factor

Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic ac...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2009-06, Vol.29 (6), p.789-791
1. Verfasser:	Ferrara, Napoleone
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - pharmacology Animals Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endothelial Cells - metabolism Fundamental and applied biological sciences. Psychology History, 20th Century History, 21st Century Humans Medical sciences Neoplasms - blood supply Neoplasms - drug therapy Neovascularization, Physiologic - drug effects Receptors, Vascular Endothelial Growth Factor - metabolism Signal Transduction - drug effects Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - history Vascular Endothelial Growth Factor A - metabolism Vertebrates: cardiovascular system
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Beschreibung
Zusammenfassung:	Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.
ISSN:	1079-5642 1524-4636
DOI:	10.1161/ATVBAHA.108.179663