Can We Measure Corneal Biomechanical Changes After Collagen Cross-Linking in Eyes With Keratoconus?-A Pilot Study
PURPOSE:To assess changes in biomechanical properties of human cornea after treatment of keratoconus with UV-A-riboflavin corneal collagen cross-linking (CXL). DESIGN:Single-center, prospective, interventional study. METHODS:Ten eyes of 10 patients aged 26.5 ± 5.7 (mean ± SD) years with progressive...
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Veröffentlicht in: | Cornea 2009-06, Vol.28 (5), p.498-502 |
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Zusammenfassung: | PURPOSE:To assess changes in biomechanical properties of human cornea after treatment of keratoconus with UV-A-riboflavin corneal collagen cross-linking (CXL).
DESIGN:Single-center, prospective, interventional study.
METHODS:Ten eyes of 10 patients aged 26.5 ± 5.7 (mean ± SD) years with progressive keratoconus were treated with UV-A-riboflavin CXL and assessed with the Ocular Response Analyzer (ORA) that measured corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal compensated intraocular pressure (IOPcc). Intraocular pressure was also measured by Goldmann applanation tonometry (GAT-IOP). Patients were assessed with ORA preoperatively, at week 1, months 1, 3, and 6 after treatment. Postoperative measurements at each visit were compared with preoperative values.
RESULTS:CH and CRF were transiently elevated after cross-linking treatment, with the difference not statistically significant (P > 0.3). IOPcc and IOPg were statistically significantly higher at 1 week and 1 month but not subsequently (P < 0.04). GAT-IOP was statistically significantly higher at 1 week and at 1 and 3 months (P < 0.01).
CONCLUSIONS:There were no significant differences in corneal biomechanical properties, as measured with the ORA parameters CH and CRF, after CXL in keratoconus. IOPcc, IOPg, and GAT-IOP values were transiently elevated after CXL treatment in our study. Whether this reflects a measurement artifact resulting from corneal changes or true elevation of intraocular pressure is unclear. |
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ISSN: | 0277-3740 1536-4798 |
DOI: | 10.1097/ICO.0b013e318190734d |