Neurogenesis in G minor

The orientation of the mitotic spindle determines whether divisions of the polarized neural progenitors in the ventricular zone cause their expansion or lead to neurogenesis. A guanine nucleotide exchange factor for the small GTPase RhoA is now shown to tip this balance in favor of neurogenesis.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature neuroscience 2009-06, Vol.12 (6), p.669-671
Hauptverfasser:	Marzesco, Anne-Marie, Mora-Bermudez, Felipe, Huttner, Wieland B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Cell Differentiation Cell Lineage - physiology Cell Polarity - physiology Cell Proliferation Cerebral Cortex - cytology Cerebral Cortex - embryology Cerebral Cortex - physiology Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Humans Mitosis - physiology Neurobiology Neurogenesis - physiology Neurons - cytology Neurons - metabolism Neurosciences news-and-views rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism Spindle Apparatus - metabolism Spindle Apparatus - ultrastructure Stem Cells - cytology Stem Cells - metabolism
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Beschreibung
Zusammenfassung:	The orientation of the mitotic spindle determines whether divisions of the polarized neural progenitors in the ventricular zone cause their expansion or lead to neurogenesis. A guanine nucleotide exchange factor for the small GTPase RhoA is now shown to tip this balance in favor of neurogenesis.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/nn0609-669