Xenon-129 Biosensor for Monitoring MHC-Peptide Interactions
Caged in: The formation of a complex between a peptide ligand and a major histocompatibility complex (MHC) class II protein is detected by a ¹²⁹Xe biosensor. Cryptophane molecules that trap Xe atoms are modified with a hemagglutinin (HA) peptide, which binds to the MHC protein. The interaction can b...
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| Veröffentlicht in: | Angewandte Chemie (International ed.) 2009-05, Vol.48 (23), p.4142-4145 |
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| container_issue | 23 |
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| container_title | Angewandte Chemie (International ed.) |
| container_volume | 48 |
| creator | Schlundt, Andreas Kilian, Wolfgang Beyermann, Michael Sticht, Jana Günther, Sebastian Höpner, Sabine Falk, Kirsten Roetzschke, Olaf Mitschang, Lorenz Freund, Christian |
| description | Caged in: The formation of a complex between a peptide ligand and a major histocompatibility complex (MHC) class II protein is detected by a ¹²⁹Xe biosensor. Cryptophane molecules that trap Xe atoms are modified with a hemagglutinin (HA) peptide, which binds to the MHC protein. The interaction can be monitored by an NMR chemical shift change of cage-HA bound ¹²⁹Xe. |
| doi_str_mv | 10.1002/anie.200806149 |
| format | Article |
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Cryptophane molecules that trap Xe atoms are modified with a hemagglutinin (HA) peptide, which binds to the MHC protein. 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| fulltext | fulltext |
| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie (International ed.), 2009-05, Vol.48 (23), p.4142-4145 |
| issn | 1433-7851 1521-3773 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | antigens Biosensing Techniques biosensors Cell Line Hemagglutinins - chemistry Histocompatibility Antigens Class II - chemistry Histocompatibility Antigens Class II - metabolism Humans Macromolecular Substances - chemistry NMR spectroscopy Nuclear Magnetic Resonance, Biomolecular peptides Polycyclic Compounds Protein Interaction Mapping - methods Triazoles - chemistry xenon Xenon Isotopes - chemistry |
| title | Xenon-129 Biosensor for Monitoring MHC-Peptide Interactions |
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