Xenon-129 Biosensor for Monitoring MHC-Peptide Interactions

Caged in: The formation of a complex between a peptide ligand and a major histocompatibility complex (MHC) class II protein is detected by a ¹²⁹Xe biosensor. Cryptophane molecules that trap Xe atoms are modified with a hemagglutinin (HA) peptide, which binds to the MHC protein. The interaction can b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie (International ed.) 2009-05, Vol.48 (23), p.4142-4145
Hauptverfasser:	Schlundt, Andreas, Kilian, Wolfgang, Beyermann, Michael, Sticht, Jana, Günther, Sebastian, Höpner, Sabine, Falk, Kirsten, Roetzschke, Olaf, Mitschang, Lorenz, Freund, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	antigens Biosensing Techniques biosensors Cell Line Hemagglutinins - chemistry Histocompatibility Antigens Class II - chemistry Histocompatibility Antigens Class II - metabolism Humans Macromolecular Substances - chemistry NMR spectroscopy Nuclear Magnetic Resonance, Biomolecular peptides Polycyclic Compounds Protein Interaction Mapping - methods Triazoles - chemistry xenon Xenon Isotopes - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Caged in: The formation of a complex between a peptide ligand and a major histocompatibility complex (MHC) class II protein is detected by a ¹²⁹Xe biosensor. Cryptophane molecules that trap Xe atoms are modified with a hemagglutinin (HA) peptide, which binds to the MHC protein. The interaction can be monitored by an NMR chemical shift change of cage-HA bound ¹²⁹Xe.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200806149