Ethnicity Does Not Affect the Homocysteine-Lowering Effect of B-Vitamin Therapy in Singaporean Stroke Patients
Increased total homocysteine (tHcy) is a risk factor for stroke. This study examines whether the efficacy of B-vitamins in reducing tHcy is modified by ethnicity in a Singaporean ischemic stroke population. 505 patients (419 Chinese, 41 Malays and 45 Indians) with ischemic stroke were randomized to...
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| Veröffentlicht in: | Stroke (1970) 2009-06, Vol.40 (6), p.2209-2211 |
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| container_title | Stroke (1970) |
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| creator | KASIMAN, Katherine EIKELBOOM, John W HANKEY, Graeme J LEE, Samantha P.-K LIM, Joanna P.-Z LEE, Jasinda H.-Q CHANG, Hui-Meng WONG, Meng-Cheong CHEN, Christopher P. L.-H |
| description | Increased total homocysteine (tHcy) is a risk factor for stroke. This study examines whether the efficacy of B-vitamins in reducing tHcy is modified by ethnicity in a Singaporean ischemic stroke population.
505 patients (419 Chinese, 41 Malays and 45 Indians) with ischemic stroke were randomized to receive placebo or B-vitamins. Fasting blood samples collected at baseline and 1 year were assayed for tHcy. MTHFR polymorphisms were genotyped.
Ethnicity did not independently determine tHcy at baseline. The magnitude of tHcy reduction by B-vitamin treatment was consistent across ethnic groups (Chinese -3.8+/-4.5, Malay -4.9+/-4.2, and Indian -3.3+/-3.6 micromol/L) despite ethnic differences in MTHFR genotype and baseline folic acid (FA) and vitamin B(12) (vitB(12)) concentrations.
Ethnicity does not appear to affect the tHcy-lowering effect of B-vitamins, despite differences in dietary intake and prevalence of MTHFR polymorphisms. This suggests that the effect of B-vitamins in lowering tHcy is generalizable across Asian populations. However, due to relatively small numbers of non-Chinese studied, confirmation in other populations is required. |
| doi_str_mv | 10.1161/STROKEAHA.108.535237 |
| format | Article |
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505 patients (419 Chinese, 41 Malays and 45 Indians) with ischemic stroke were randomized to receive placebo or B-vitamins. Fasting blood samples collected at baseline and 1 year were assayed for tHcy. MTHFR polymorphisms were genotyped.
Ethnicity did not independently determine tHcy at baseline. The magnitude of tHcy reduction by B-vitamin treatment was consistent across ethnic groups (Chinese -3.8+/-4.5, Malay -4.9+/-4.2, and Indian -3.3+/-3.6 micromol/L) despite ethnic differences in MTHFR genotype and baseline folic acid (FA) and vitamin B(12) (vitB(12)) concentrations.
Ethnicity does not appear to affect the tHcy-lowering effect of B-vitamins, despite differences in dietary intake and prevalence of MTHFR polymorphisms. This suggests that the effect of B-vitamins in lowering tHcy is generalizable across Asian populations. However, due to relatively small numbers of non-Chinese studied, confirmation in other populations is required.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.108.535237</identifier><identifier>PMID: 19372453</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Biological and medical sciences ; China - ethnology ; Diet ; Ethnic Groups ; Female ; Folic Acid - blood ; Gene Frequency ; Genotype ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Homocysteine - antagonists & inhibitors ; Homocysteine - blood ; Humans ; India - ethnology ; Malaysia - ethnology ; Male ; Medical sciences ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Risk Factors ; Singapore - epidemiology ; Stroke - blood ; Vascular diseases and vascular malformations of the nervous system ; Vitamin B Complex - therapeutic use</subject><ispartof>Stroke (1970), 2009-06, Vol.40 (6), p.2209-2211</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-95a84ba01d8e8745c9156b05c90f51ce455d4ca1c86481dedcaa3dff38664c103</citedby><cites>FETCH-LOGICAL-c417t-95a84ba01d8e8745c9156b05c90f51ce455d4ca1c86481dedcaa3dff38664c103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21548901$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19372453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KASIMAN, Katherine</creatorcontrib><creatorcontrib>EIKELBOOM, John W</creatorcontrib><creatorcontrib>HANKEY, Graeme J</creatorcontrib><creatorcontrib>LEE, Samantha P.-K</creatorcontrib><creatorcontrib>LIM, Joanna P.-Z</creatorcontrib><creatorcontrib>LEE, Jasinda H.-Q</creatorcontrib><creatorcontrib>CHANG, Hui-Meng</creatorcontrib><creatorcontrib>WONG, Meng-Cheong</creatorcontrib><creatorcontrib>CHEN, Christopher P. L.-H</creatorcontrib><title>Ethnicity Does Not Affect the Homocysteine-Lowering Effect of B-Vitamin Therapy in Singaporean Stroke Patients</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Increased total homocysteine (tHcy) is a risk factor for stroke. This study examines whether the efficacy of B-vitamins in reducing tHcy is modified by ethnicity in a Singaporean ischemic stroke population.
505 patients (419 Chinese, 41 Malays and 45 Indians) with ischemic stroke were randomized to receive placebo or B-vitamins. Fasting blood samples collected at baseline and 1 year were assayed for tHcy. MTHFR polymorphisms were genotyped.
Ethnicity did not independently determine tHcy at baseline. The magnitude of tHcy reduction by B-vitamin treatment was consistent across ethnic groups (Chinese -3.8+/-4.5, Malay -4.9+/-4.2, and Indian -3.3+/-3.6 micromol/L) despite ethnic differences in MTHFR genotype and baseline folic acid (FA) and vitamin B(12) (vitB(12)) concentrations.
Ethnicity does not appear to affect the tHcy-lowering effect of B-vitamins, despite differences in dietary intake and prevalence of MTHFR polymorphisms. This suggests that the effect of B-vitamins in lowering tHcy is generalizable across Asian populations. However, due to relatively small numbers of non-Chinese studied, confirmation in other populations is required.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>China - ethnology</subject><subject>Diet</subject><subject>Ethnic Groups</subject><subject>Female</subject><subject>Folic Acid - blood</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Homocysteine - antagonists & inhibitors</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>India - ethnology</subject><subject>Malaysia - ethnology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Risk Factors</subject><subject>Singapore - epidemiology</subject><subject>Stroke - blood</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Vitamin B Complex - therapeutic use</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFO4zAURS00CDrAH4xG3gy7FL_YTpxlKZ0pogIEhW3kOs_U0MTFdjXq3xPUClbv6uncuziE_AI2BCjg4nH-cHczGU1HQ2BqKLnMeXlABiBzkYkiVz_IgDFeZbmoqmPyM8ZXxljOlTwix1DxMheSD0g3ScvOGZe29MpjpLc-0ZG1aBJNS6RT33qzjQldh9nM_8fguhc62QHe0svs2SXduo7Olxj0ekv7-Ngzeu0D6j6n4N-Q3uvksEvxlBxavYp4tr8n5OnvZD6eZrO7f9fj0SwzAsqUVVIrsdAMGoWqFNJUIIsF6y-zEgwKKRthNBhVCAUNNkZr3ljLVVEIA4yfkPPd7jr49w3GVLcuGlytdId-E-uizEtZlGUPih1ogo8xoK3XwbU6bGtg9afn-stz_1H1znNf-73f3yxabL5Le7E98GcP6Gj0ygbdGRe_uBykUBUD_gEzkYd-</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>KASIMAN, Katherine</creator><creator>EIKELBOOM, John W</creator><creator>HANKEY, Graeme J</creator><creator>LEE, Samantha P.-K</creator><creator>LIM, Joanna P.-Z</creator><creator>LEE, Jasinda H.-Q</creator><creator>CHANG, Hui-Meng</creator><creator>WONG, Meng-Cheong</creator><creator>CHEN, Christopher P. L.-H</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090601</creationdate><title>Ethnicity Does Not Affect the Homocysteine-Lowering Effect of B-Vitamin Therapy in Singaporean Stroke Patients</title><author>KASIMAN, Katherine ; EIKELBOOM, John W ; HANKEY, Graeme J ; LEE, Samantha P.-K ; LIM, Joanna P.-Z ; LEE, Jasinda H.-Q ; CHANG, Hui-Meng ; WONG, Meng-Cheong ; CHEN, Christopher P. L.-H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-95a84ba01d8e8745c9156b05c90f51ce455d4ca1c86481dedcaa3dff38664c103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>China - ethnology</topic><topic>Diet</topic><topic>Ethnic Groups</topic><topic>Female</topic><topic>Folic Acid - blood</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Homocysteine - antagonists & inhibitors</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>India - ethnology</topic><topic>Malaysia - ethnology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Risk Factors</topic><topic>Singapore - epidemiology</topic><topic>Stroke - blood</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Vitamin B Complex - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KASIMAN, Katherine</creatorcontrib><creatorcontrib>EIKELBOOM, John W</creatorcontrib><creatorcontrib>HANKEY, Graeme J</creatorcontrib><creatorcontrib>LEE, Samantha P.-K</creatorcontrib><creatorcontrib>LIM, Joanna P.-Z</creatorcontrib><creatorcontrib>LEE, Jasinda H.-Q</creatorcontrib><creatorcontrib>CHANG, Hui-Meng</creatorcontrib><creatorcontrib>WONG, Meng-Cheong</creatorcontrib><creatorcontrib>CHEN, Christopher P. L.-H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KASIMAN, Katherine</au><au>EIKELBOOM, John W</au><au>HANKEY, Graeme J</au><au>LEE, Samantha P.-K</au><au>LIM, Joanna P.-Z</au><au>LEE, Jasinda H.-Q</au><au>CHANG, Hui-Meng</au><au>WONG, Meng-Cheong</au><au>CHEN, Christopher P. L.-H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethnicity Does Not Affect the Homocysteine-Lowering Effect of B-Vitamin Therapy in Singaporean Stroke Patients</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>40</volume><issue>6</issue><spage>2209</spage><epage>2211</epage><pages>2209-2211</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Increased total homocysteine (tHcy) is a risk factor for stroke. This study examines whether the efficacy of B-vitamins in reducing tHcy is modified by ethnicity in a Singaporean ischemic stroke population.
505 patients (419 Chinese, 41 Malays and 45 Indians) with ischemic stroke were randomized to receive placebo or B-vitamins. Fasting blood samples collected at baseline and 1 year were assayed for tHcy. MTHFR polymorphisms were genotyped.
Ethnicity did not independently determine tHcy at baseline. The magnitude of tHcy reduction by B-vitamin treatment was consistent across ethnic groups (Chinese -3.8+/-4.5, Malay -4.9+/-4.2, and Indian -3.3+/-3.6 micromol/L) despite ethnic differences in MTHFR genotype and baseline folic acid (FA) and vitamin B(12) (vitB(12)) concentrations.
Ethnicity does not appear to affect the tHcy-lowering effect of B-vitamins, despite differences in dietary intake and prevalence of MTHFR polymorphisms. This suggests that the effect of B-vitamins in lowering tHcy is generalizable across Asian populations. However, due to relatively small numbers of non-Chinese studied, confirmation in other populations is required.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>19372453</pmid><doi>10.1161/STROKEAHA.108.535237</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Stroke (1970), 2009-06, Vol.40 (6), p.2209-2211 |
| issn | 0039-2499 1524-4628 |
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| source | MEDLINE; American Heart Association; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Biological and medical sciences China - ethnology Diet Ethnic Groups Female Folic Acid - blood Gene Frequency Genotype Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Homocysteine - antagonists & inhibitors Homocysteine - blood Humans India - ethnology Malaysia - ethnology Male Medical sciences Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged Nervous system (semeiology, syndromes) Neurology Risk Factors Singapore - epidemiology Stroke - blood Vascular diseases and vascular malformations of the nervous system Vitamin B Complex - therapeutic use |
| title | Ethnicity Does Not Affect the Homocysteine-Lowering Effect of B-Vitamin Therapy in Singaporean Stroke Patients |
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