CLC-7: A potential therapeutic target for the treatment of osteoporosis and neurodegeneration

CLC-7 is a member of the voltage-gated chloride channels family. It resides mainly in the late endosomes, lysosomes and the ruffled membrane of osteoclasts. Mice deficient in the ubiquitously expressed ClC-7 Cl − channel show severe osteopetrosis and retinal degeneration. In the present review, some...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-07, Vol.384 (3), p.277-279
Hauptverfasser:	Zhao, Qingxiao, Wei, Qun, He, Aimin, Jia, Ruokun, Xiao, Yongtao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chloride Channels - antagonists & inhibitors Chloride Channels - genetics Chloride Channels - metabolism CLC-7 Endosomes Humans Lysosomes Mice Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Osteoclasts Osteopetrosis - drug therapy Osteopetrosis - genetics Osteopetrosis - metabolism Retinal Degeneration - drug therapy Retinal Degeneration - genetics Retinal Degeneration - metabolism
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Zusammenfassung:	CLC-7 is a member of the voltage-gated chloride channels family. It resides mainly in the late endosomes, lysosomes and the ruffled membrane of osteoclasts. Mice deficient in the ubiquitously expressed ClC-7 Cl − channel show severe osteopetrosis and retinal degeneration. In the present review, some of the known features of CLC-7 such as structure, function and its roles in physiological or pathophysiological processes are highlighted.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/j.bbrc.2009.04.088