Recipient Genotype Is a Predictor of Allograft Cytokine Expression and Outcomes After Pediatric Cardiac Transplantation

Objectives This study sought to investigate the influence of recipient renin-angiotensin-aldosterone system (RAAS) genotype on cardiac function, rejection, and outcomes after heart transplantation. Background The RAAS influences cardiac function and up-regulates inflammatory/immune pathways. Little...

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Veröffentlicht in:	Journal of the American College of Cardiology 2009-05, Vol.53 (20), p.1909-1917
Hauptverfasser:	Auerbach, Scott R., MD, Manlhiot, Cedric, BS, Reddy, Sushma, MD, Kinnear, Caroline, MS, Richmond, Marc E., MD, Gruber, Dorota, MS, McCrindle, Brian W., MD, MPH, Deng, Liyong, MS, Chen, Jonathan M., MD, Addonizio, Linda J., MD, Chung, Wendy K., MD, Mital, Seema, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Age angiotensin Biological and medical sciences Biopsy cardiac transplantation Cardiology Cardiology. Vascular system Cardiomyopathies - surgery Cardiovascular Cardiovascular disease Child cytokines Deoxyribonucleic acid DNA DNA - genetics Drug therapy Echocardiography Enzymes Ethnicity Female Follow-Up Studies Gene Expression Regulation Genes genetics Genotype Genotype & phenotype Graft Rejection - diagnosis Graft Rejection - genetics Graft Rejection - metabolism Heart Heart Defects, Congenital - surgery Heart Transplantation Humans Interleukin-6 - biosynthesis Interleukin-6 - genetics Internal Medicine Intubation Male Medical records Medical sciences Mortality Myocardium - metabolism Myocardium - pathology Patients Pediatrics Polymerase Chain Reaction Polymorphism Pulmonary arteries Retrospective Studies Risk Factors Rodents Studies Time Factors Transforming Growth Factor alpha - biosynthesis Transforming Growth Factor alpha - genetics Transforming Growth Factor beta - biosynthesis Transforming Growth Factor beta - genetics Transplantation, Homologous
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Beschreibung
Zusammenfassung:	Objectives This study sought to investigate the influence of recipient renin-angiotensin-aldosterone system (RAAS) genotype on cardiac function, rejection, and outcomes after heart transplantation. Background The RAAS influences cardiac function and up-regulates inflammatory/immune pathways. Little is known about the effect of recipient RAAS polymorphisms in pediatric cardiac transplantation. Methods Patients
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2009.02.027