Correlation of Decreased Survival and IL-18 in Bone Metastasis

Objective Previous studies have reported that serum IL-18 levels are increased in some cancers. We investigated whether IL-18 production is increased in sera and cancer cells of patients with non-small cell lung cancer (NSCLC). Patients or Materials Serum levels of IFN-γ and IL-18 and thioredoxin 1...

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Veröffentlicht in:Internal Medicine 2009, Vol.48(10), pp.763-773
Hauptverfasser: Okamoto, Masaki, Azuma, Koichi, Hoshino, Tomoaki, Imaoka, Haruki, Ikeda, Jiro, Kinoshita, Takashi, Takamori, Shinzo, Ohshima, Koichi, Edakuni, Nobutaka, Kato, Seiya, Iwanaga, Tomoaki, Aizawa, Hisamichi
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Sprache:eng
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Zusammenfassung:Objective Previous studies have reported that serum IL-18 levels are increased in some cancers. We investigated whether IL-18 production is increased in sera and cancer cells of patients with non-small cell lung cancer (NSCLC). Patients or Materials Serum levels of IFN-γ and IL-18 and thioredoxin 1 (TRX1) were measured in 79 patients (51 males, 28 females, median age 67 years) with advanced NSCLC (57 adenocarcinoma, 22 squamous cell carcinoma; TNM stages IIIA [n=11], IIIB [n=24], and IV [n=44]) and 75 healthy age-matched controls (44 males, 31 females, median age 65 years) by enzyme-linked immunosorbent assay. We examined IL-18 production in the lungs and sites of bone metastasis of adenocarcinoma by immunohistochemistry. Results Serum IL-18, IFN-γ, and TRX1 levels in NSCLC patients were significantly (p
ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.48.1851