Phagocytosis, Oxidative Burst, and Produced Reactive Species are Affected by Iron Deficiency Anemia and Anemia of Chronic Diseases in Elderly

Phagocytosis, Oxidative Burst, and Produced Reactive Species are Affected by Iron Deficiency Anemia and Anemia of Chronic Diseases in Elderly

Iron and oxidative stress have a regulatory interplay. During the oxidative burst, phagocytic cells produce free radicals such as hypochlorous acid (HOCl). Nevertheless, scarce studies evaluated the effect of either iron deficiency anemia (IDA) or anemia of chronic disease (ACD) on phagocyte functio...

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Veröffentlicht in:Biological trace element research 2009-06, Vol.129 (1-3), p.116-125
Hauptverfasser: Paino, I. M. M., Miranda, J. C., Marzocchi-Machado, C. M., Cesarino, E. J., de Castro, F. A., de Souza, A. M.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Aged, 80 and over
Anemia
Anemia - metabolism
Anemia, Iron-Deficiency - metabolism
Biochemistry
Biomedical and Life Sciences
Biotechnology
Cells, Cultured
Chronic Disease
Disease
Female
Free Radical Scavengers - metabolism
Free radicals
Humans
Hypochlorous Acid - metabolism
Iron
Life Sciences
Male
Middle Aged
Monocytes - metabolism
Neutrophils - metabolism
Nitric oxide
Nitric Oxide - metabolism
Nutrient deficiency
Nutrition
Older people
Oncology
Oxidative stress
Phagocytosis
Public health
Reactive Oxygen Species - metabolism
Respiratory Burst
Studies
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Zusammenfassung:Iron and oxidative stress have a regulatory interplay. During the oxidative burst, phagocytic cells produce free radicals such as hypochlorous acid (HOCl). Nevertheless, scarce studies evaluated the effect of either iron deficiency anemia (IDA) or anemia of chronic disease (ACD) on phagocyte function in the elderly. The aim of the present study was to determine the oxidative burst, phagocytosis, and nitric oxide ( • NO) and HOCl, reactive species produced by monocytes and neutrophils in elderly with ACD or IDA. Soluble transferrin receptor, serum ferritin, and soluble transferrin receptor/log ferritin (TfR-F) index determined the iron status. The study was constituted of 39 patients aged over 60 (28 women and 11 men) recruited from the Brazilian Public Health System. Oxidative burst fluorescence intensity per neutrophil in IDA group and HOCl generation in both ACD and IDA groups were found to be lower ( p  
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-008-8303-8