Kinetically locked luminescent metallomacrocycles as duplex DNA binding substrates

A self-assembled, kinetically locked, tetranuclear metallomacrocycle interacts with duplex DNA with an affinity that is several orders of magnitude higher than its mononuclear building blocks, producing large-scale bending of the duplex structure.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2009-05 (20), p.2947-2949
Hauptverfasser:	Ghosh, Dipesh, Ahmad, Haslina, A Thomas, Jim
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites DNA - chemistry DNA - metabolism Luminescence Macrocyclic Compounds - chemistry Macrocyclic Compounds - metabolism Metals - chemistry Metals - metabolism Nucleic Acid Conformation
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A self-assembled, kinetically locked, tetranuclear metallomacrocycle interacts with duplex DNA with an affinity that is several orders of magnitude higher than its mononuclear building blocks, producing large-scale bending of the duplex structure.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b901366k