Urinary levels of B-type natriuretic peptide (BNP) and ventricular systolic dysfunction in heart failure patients

It was aimed to compare urine B-type natriuretic peptide (BNP) according to left ventricular systolic dysfunction and to investigate its diagnostic value in heart failure (HF) patients. A total of 90 HF outpatients (61 men, age 66 +/- 12) and 30 age- and gender-matched controls were studied. An increase in urine BNP was observed in patients with EF 40% (p < 0.0001), and controls (p < 0.0001). Significant correlations between urinary BNP and left ventricular functional parameters were obtained. A multivariate regression analysis was performed and the best model associated with urine BNP included plasma BNP (p < 0.0001), EF (p = 0.02) and LV volume indexes (p < 0.0001). The ROC for detection of EF