Vascular endothelial growth factor A and C gene expression in endometriosis

Angiogenesis is essential for the pathogenesis of endometriosis. Gene expression levels of vascular endothelial growth factor (VEGF) A and C in 10 eutopic endometrial, 23 normal peritoneal, and 62 endometriotic tissues surgically obtained from 47 women with endometriosis (group 2) were compared with...

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Veröffentlicht in:	Human pathology 2004-11, Vol.35 (11), p.1369-1375
Hauptverfasser:	Takehara, Mikio, Ueda, Masatsugu, Yamashita, Yoshiki, Terai, Yoshito, Hung, Yao-Ching, Ueki, Minoru
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Biological and medical sciences DNA Primers - chemistry Endometriosis Endometriosis - genetics Endometriosis - metabolism Endometriosis - pathology Endometrium - blood supply Endometrium - metabolism Endometrium - pathology Female Female genital diseases Gene Expression Gynecology. Andrology. Obstetrics Humans Immunoenzyme Techniques Investigative techniques, diagnostic techniques (general aspects) lymphangiogenesis Medical sciences Menstrual Cycle - metabolism Neovascularization, Pathologic Non tumoral diseases Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Peritoneum - metabolism Peritoneum - pathology Proteins Reproductive health Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Vascular endothelial growth factor vascular endothelial growth factor A Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism vascular endothelial growth factor C Vascular Endothelial Growth Factor C - genetics Vascular Endothelial Growth Factor C - metabolism
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Zusammenfassung:	Angiogenesis is essential for the pathogenesis of endometriosis. Gene expression levels of vascular endothelial growth factor (VEGF) A and C in 10 eutopic endometrial, 23 normal peritoneal, and 62 endometriotic tissues surgically obtained from 47 women with endometriosis (group 2) were compared with those in 12 control eutopic endometrial and 9 normal peritoneal tissues from 15 women without endometriosis (group 1). VEGF-A mRNA expression levels in eutopic endometrium of group 2 were higher than those of group 1 throughout the menstrual cycle ( P
ISSN:	0046-8177 1532-8392
DOI:	10.1016/j.humpath.2004.07.020