Flavopiridol: an antitumor drug with potential application in the treatment of neurodegenerative diseases

Several lines of evidence show that cyclin-dependent kinases (CDKs) contribute to neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, and amyotrophic lateral sclerosis. Given their role in the neuronal apoptosis, the inhibition of CDKs by specific drugs such as flavop...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Medical hypotheses 2005, Vol.64 (1), p.120-123
Hauptverfasser:	Pallàs, M., Verdaguer, E., Jordà, E.G., Jiménez, A., Canudas, A.M., Camins, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Apoptosis - drug effects Clinical Trials as Topic Cyclin-Dependent Kinases - antagonists & inhibitors Cyclin-Dependent Kinases - metabolism Flavoproteins - administration & dosage Humans Models, Neurological Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - metabolism Neurons - drug effects Neurons - metabolism Neuroprotective Agents - administration & dosage
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Several lines of evidence show that cyclin-dependent kinases (CDKs) contribute to neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, and amyotrophic lateral sclerosis. Given their role in the neuronal apoptosis, the inhibition of CDKs by specific drugs such as flavopiridol may be a valid therapeutic approach. Expression of CDKs was observed in rodent models of excitotoxicity and stroke, and CDK inhibitors showed neuroprotective effects. Flavopiridol may provide significant improvement in neurodegenerative diseases in humans.
ISSN:	0306-9877 1532-2777
DOI:	10.1016/j.mehy.2004.03.047