HER2 Polysomy in aggressive head and neck cutaneous squamous cell carcinoma
Furthermore, although cases with HER2 gene amplification were characteristically high-grade tumors associated with estrogen receptor negativity and reduced disease-free survival, cases with polysomy 17 alone did not show significant association with adverse clinicopathologic parameters. In non-small...
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| Veröffentlicht in: | Human pathology 2009-06, Vol.40 (6), p.902-903 |
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| creator | Low, Irene, MBChB, FRCPA Ch'ng, Sydney, MBBS Ng, Daniel, BSc Sullivan, Michael, MBChB, FRACP, PhD Brasch, Helen, MBChB, FRCPA Davis, Paul, PhD Tan, Swee Thong, MBBS, FRACS, PhD |
| description | Furthermore, although cases with HER2 gene amplification were characteristically high-grade tumors associated with estrogen receptor negativity and reduced disease-free survival, cases with polysomy 17 alone did not show significant association with adverse clinicopathologic parameters. In non-small cell lung carcinoma, high copy numbers of the HER2 gene has been demonstrated to be of significance in predicting therapeutic response to EGFR-targeted tyrosine kinase inhibitors, such as gefitinib [5]. |
| doi_str_mv | 10.1016/j.humpath.2008.12.012 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0046-8177 |
| ispartof | Human pathology, 2009-06, Vol.40 (6), p.902-903 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Aged, 80 and over Breast cancer Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Gene amplification Gene Expression Regulation, Neoplastic Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Humans Kinases Middle Aged Pathology Proteins Receptor, ErbB-2 - genetics Tumors |
| title | HER2 Polysomy in aggressive head and neck cutaneous squamous cell carcinoma |
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