Factor XI Deficiency and Obstetrical Anesthesia

Factor XI Deficiency and Obstetrical Anesthesia

Factor XI (FXI) deficiency is a rare inherited coagulation disorder associated with prolonged activated partial thromboplastin time. The severity of bleeding often does not correlate with plasma factor levels. We reviewed the medical and anesthetic records of 13 parturients with FXI deficiency that...

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Veröffentlicht in:Anesthesia and analgesia 2009-06, Vol.108 (6), p.1882-1885
Hauptverfasser: Singh, Amarjeet, Harnett, Miriam J., Connors, Jean M., Camann, William R.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Analgesia, Obstetrical
Anesthesia
Anesthesia, Epidural
Anesthesia, General
Anesthesia, Spinal
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Coagulation
Cesarean Section
Factor XI Deficiency - complications
Female
Humans
Medical sciences
Partial Thromboplastin Time
Plasma
Pregnancy
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Zusammenfassung:Factor XI (FXI) deficiency is a rare inherited coagulation disorder associated with prolonged activated partial thromboplastin time. The severity of bleeding often does not correlate with plasma factor levels. We reviewed the medical and anesthetic records of 13 parturients with FXI deficiency that presented for delivery. Nine cases were managed with neuraxial anesthesia. (epidural, seven; spinal, one; combined spinal-epidural, one). Three received general anesthesia for cesarean delivery, and one had an unmedicated vaginal delivery. Baseline factor levels ranged from severe (
ISSN:0003-2999
1526-7598
DOI:10.1213/ane.0b013e3181a28715