The Thymus Plays a Role in Oral Tolerance Induction in Experimental Autoimmune Encephalomyelitis

: Mice are protected from experimental autoimmune encephalomyelitis (EAE) when fed myelin basic protein (MBP). Thymectomized mice do not exhibit oral tolerance. We found evidence for two mechanisms to explain the role of the thymus in oral tolerance: a site for deletion of autoreactive T cells and a...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2004-12, Vol.1029 (1), p.402-404
Hauptverfasser:	SONG, FEI, GIENAPP, INGRID E., SHAWLER, TODD, GUAN, ZHEN, WHITACRE, CAROLINE C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals autoimmunity EAE/MS Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - prevention & control Immune Tolerance Immunity, Mucosal Mice Mice, Transgenic Mouth Mucosa - immunology Myelin Basic Protein - immunology Myelin Basic Protein - therapeutic use oral tolerance Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology T cell receptor Thymectomy thymus Thymus Gland - immunology
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Zusammenfassung:	: Mice are protected from experimental autoimmune encephalomyelitis (EAE) when fed myelin basic protein (MBP). Thymectomized mice do not exhibit oral tolerance. We found evidence for two mechanisms to explain the role of the thymus in oral tolerance: a site for deletion of autoreactive T cells and a source of regulatory T cells.
ISSN:	0077-8923 1749-6632
DOI:	10.1196/annals.1309.047