Fractional Flow Reserve for Guiding PCI

To the Editor: Tonino et al. (Jan. 15 issue) 1 report on the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) study (ClinicalTrials.gov number, NCT00267774), which compared an angiography-only strategy with routine measurement of fractional flow reserve (FFR) in addition to angiography in patients with multivessel disease who were undergoing percutaneous coronary intervention (PCI). The authors report a lower 1-year rate of adverse events with angiography guided by FFR measurement. Although their findings provide an encouraging perspective on the relative safety of selective stenting with the use of FFR measurement, some aspects of the trial design may have led to . . .