Dementia in idiopathic Parkinson's syndrome

Approximately 25% of patients with idiopathic Parkinson's disease (IPD) later develop dementia, with the typical characteristics as detailed in ICD-10 and DSM-IV. Differential diagnosis has to exclude dementia due to Lewy bodies, subcortical vascular encephalopathy and subcortical dementia due...

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Veröffentlicht in:	Journal of neurology 2004-09, Vol.251 Suppl 6, p.VI/28-VI/32
Hauptverfasser:	Fuchs, Gerd A, Gemende, Irene, Herting, Birgit, Lemke, Mathias R, Oehlwein, Christian, Reichmann, Heinz, Rieke, Jürgen, Emmans, David, Volkmann, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	Cholinesterase Inhibitors - pharmacology Cholinesterase Inhibitors - therapeutic use Dementia Dementia - diagnosis Dementia - drug therapy Dementia - physiopathology Diagnosis, Differential Humans Lewy Body Disease - diagnosis Lewy Body Disease - physiopathology Neurology Neuropsychology Parkinson Disease - complications Parkinson Disease - physiopathology Parkinson Disease - psychology Parkinson's disease Supranuclear Palsy, Progressive - diagnosis Supranuclear Palsy, Progressive - physiopathology Treatment Outcome
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Zusammenfassung:	Approximately 25% of patients with idiopathic Parkinson's disease (IPD) later develop dementia, with the typical characteristics as detailed in ICD-10 and DSM-IV. Differential diagnosis has to exclude dementia due to Lewy bodies, subcortical vascular encephalopathy and subcortical dementia due to progressive supranuclear paralysis or corticobasal degeneration. Several studies showed promising results for cholinesterase inhibitors such as donepezile, rivastigmine and galantamine. The demented Parkinsonian patients then present with improvement in cognitive function while motor skills do not deteriorate.
ISSN:	0340-5354 1432-1459
DOI:	10.1007/s00415-004-1607-5