Freeze-drying of protein pharmaceuticals: the application of thermal analysis

Freeze-drying of protein pharmaceuticals: the application of thermal analysis

This review describes the range of thermal analysis techniques that may be used to investigate the key thermal properties of formulations to be freeze-dried and the resultant products. The use of these allows development of cost-effective processing while maintaining optimum product quality.

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Veröffentlicht in:Cryo-Letters 2004-11, Vol.25 (6), p.389-404
Hauptverfasser: Kett, Vicky P, McMahon, Debra, Ward, Kevin
Format: Artikel
Sprache:eng
Schlagworte:
Calorimetry
Cryoprotectant
Differential Thermal Analysis
Drug Stability
Electric Impedance
Freeze Drying
Glass Transition
Lyophilization
Microscopy
Pharmaceutical Preparations
Protein
Proteins
Review
Stress, Mechanical
Thermal Analysis
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Zusammenfassung:This review describes the range of thermal analysis techniques that may be used to investigate the key thermal properties of formulations to be freeze-dried and the resultant products. The use of these allows development of cost-effective processing while maintaining optimum product quality.
ISSN:0143-2044