New Camptothecin and Ellagic Acid Analogues from the Root Bark of Camptotheca acuminata

Abstract As part of a study on chemical constituents of CAMPTOTHECA species, one new natural camptothecin analogue (2), two new alkaloids (3, 4), one new ellagic acid analogue (5), and 19 known compounds (1, 6 - 23) have been isolated from the root bark, stem bark, fruits, and leaves of CAMPTOTHECA ACUMINATA Decaisne. The structures of 2 - 5 were determined from spectral data to be 10-methoxy-20-O-acetylcamptothecin (2), 20-O-β-glucopyranosyl 18-hydroxycamptothecin (3), 20-formylbenzindolizino [1,2-B]quino-line-11(13H)-one (4), and 3,4-methylenedioxy-3′-O-methyl-5′-hydroxyellagic acid (5).